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FLASH GENE
Symbol FGF22 contributors: mct - updated : 24-02-2015
HGNC name fibroblast growth factor 22
HGNC id 3679
Location 19p13.3      Physical location : 639.925 - 643.603
Synonym name fibroblast growth factor 22 precursor
DNA
TYPE functioning gene
SPECIAL FEATURE escaping inactivation
STRUCTURE 3.94 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC390871 19 similar to CXYorf1-related protein LOC390872 19 similar to Olfactory receptor 4F3 LOC388486 19 similar to bA476I15.3 (novel protein similar to septin) LOC390873 19 similar to capicua homolog LOC388487 19 LOC388487 PPAP2C 19p13 phosphatidic acid phosphatase type 2C KIAA1193 19p13.3 phosphatidic acid phosphatase type 2C THEG 19p13.3 Theg homolog (mouse) KIAA1957 19p13.3 KIAA1957 FLJ40059 19p13.3 hypothetical protein FLJ40059 MADCAM1 19p13.3 mucosal vascular addressin cell adhesion molecule 1 LOC91978 19p13.3 hypothetical gene supported by BC009520 CDC34 19p13.3 cell division cycle 34 GZMM 19p13.3 granzyme M (lymphocyte met-ase 1) BSG 19p13.3 basigin (OK blood group) HCN2 19p13.3 hyperpolarization activated cyclic nucleotide-gated potassium channel 2 POLRMT 19p13.3 polymerase (RNA) mitochondrial (DNA directed) FGF22 19p13.3 fibroblast growth factor 22 RNF126 19p13.3 ring finger protein 126 FSTL3 19p13 follistatin-like 3 (secreted glycoprotein) PALM 19p13.3 paralemmin LOC126353 19p13.3 hypothetical protein LOC126353 PTBP1 19p13.3 polypyrimidine tract binding protein 1 FLJ11535 19p13.3 hypothetical protein FLJ11535 AZU1 19p13.3 azurocidin 1 (cationic antimicrobial protein 37) PRTN3 19p13.3 proteinase 3 (serine proteinase, neutrophil, Wegener granulomatosis autoantigen) ELA2 19p13.3 elastase 2, neutrophil DF 19p13.3 D component of complement (adipsin) TRAP95 MGC16353 19p13.3 hypothetical protein MGC16353 GPR54 19p13.3 G protein-coupled receptor 54 DRIL1 19p13.3 dead ringer-like 1 (Drosophila) WDR18 19p13.3 WD repeat domain 18 GRIN3B 19p13.3 glutamate receptor, ionotropic, N-methyl-D-aspartate 3B C19orf6 19p13.3 chromosome 19 open reading frame 6 CNN2 21q11 calponin 2 ABCA7 19p13.3 ATP-binding cassette, sub-family A (ABC1), member 7 HA-1 19p13.3 ATP-binding cassette, sub-family A (ABC1), member 7 POLR2E 19p13.3 polymerase (RNA) II (DNA directed) polypeptide E, 25kDa GPX4 19p13.3 glutathione peroxidase 4 (phospholipid hydroperoxidase) KIAA0963 19p13.3 Homo sapiens KIAA0963 protein (KIAA0963), mRNA. STK11 19p13.3 serine/threonine kinase 11 (Peutz-Jeghers syndrome) MGC40084 19p13.3 hypothetical protein MGC40084 ATP5D 19p13.3 ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 513 - 170 - 2001 11342227
- - 620 - 165 - 2001 11342227
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainmidbrain    Danio rerioFetal
 brainlimbic systemhippocampus   Homo sapiens
Reproductivefemale systemovary   
Skin/Tegumentskin appendageshair  predominantly Mus musculus
cells
SystemCellPubmedSpeciesStageRna symbol
Nervouspyramidal cell Homo sapiens
Skin/Tegumenthair follicle cell Mus musculus
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
isoforms Precursor
HOMOLOGY
interspecies homolog to murine Fgf-22
Homologene
FAMILY
  • heparin-binding growth factors family
  • FGF7 subfamily
  • CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • acting as a presynaptic organizer
  • ligand of FGFR2, involved in presynaptic differentiation of mossy fibers
  • may be playing a role in hair development
  • FGF22 and SIRPA induced vesicle clusters of different sizes, differed in their ability to promote neurite branching, and acted through different receptors and signaling pathways
  • FGF22 and FGF7, promote the organization of excitatory and inhibitory presynaptic terminals, respectively, as target-derived presynaptic organizers
  • FGF22, FGF7 act as target-derived presynaptic organizers and help to organize specific presynaptic terminals in the mammalian brain
  • FGF22 is an important "organizing" cue for the timely development of retinogeniculate synapses
  • have a clear role in synaptogenesis, but also a potential pro-oncogenic role in the skin
  • plays important roles in controlling neurogenesis, ectopic migration of dentate granule cells (DGCs), and hilar cell death after seizures, which may contribute to the generalized seizure-resistant phenotype of FGF22KO mice
  • potentially involved in midbrain development downstream of FGF3 and FGF8 in the midbrain-hindbrain boundary (MHB) but not of Hh in the floor plate
  • FGF22 and FGF7 are postsynaptic-cell-derived presynaptic organizers necessary for excitatory and inhibitory presynaptic differentiation, respectively, in the hippocampus
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyepilepsy 
    inhibition of FGF22 may alleviate epileptogenesis
    ANIMAL & CELL MODELS
  • Fgf22 knockout (KO) mice show resistance to generalized seizures in adults as assessed by chemical kindling