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FLASH GENE

Symbol

FGF22

contributors: mct - updated : 24-02-2015

HGNC name	fibroblast growth factor 22
HGNC id	3679

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19p13.3      Physical location : 639.925 - 643.603
Synonym name	fibroblast growth factor 22 precursor

DNA

TYPE	functioning gene
SPECIAL FEATURE	escaping inactivation
STRUCTURE	3.94 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_020637 3 - 513 NP_065688 - 170 - 2001 11342227 NM_001300812 - - 620 NP_001287741 - 165 - 2001 11342227

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain midbrain       Danio rerio Fetal   brain limbic system hippocampus     Homo sapiens Reproductive female system ovary       Skin/Tegument skin appendages hair     predominantly Mus musculus

cells

System Cell Pubmed Species Stage Rna symbol Nervous pyramidal cell Homo sapiens Skin/Tegument hair follicle cell Mus musculus

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

isoforms

Precursor

HOMOLOGY

interspecies

homolog to murine Fgf-22

Homologene

FAMILY	heparin-binding growth factors family
	FGF7 subfamily

CATEGORY

signaling growth factor

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,Golgi
	intracellular,nucleus,nucleolus

basic FUNCTION	acting as a presynaptic organizer
	ligand of FGFR2, involved in presynaptic differentiation of mossy fibers
	may be playing a role in hair development
	FGF22 and SIRPA induced vesicle clusters of different sizes, differed in their ability to promote neurite branching, and acted through different receptors and signaling pathways
	FGF22 and FGF7, promote the organization of excitatory and inhibitory presynaptic terminals, respectively, as target-derived presynaptic organizers
	FGF22, FGF7 act as target-derived presynaptic organizers and help to organize specific presynaptic terminals in the mammalian brain
	FGF22 is an important "organizing" cue for the timely development of retinogeniculate synapses
	have a clear role in synaptogenesis, but also a potential pro-oncogenic role in the skin
	plays important roles in controlling neurogenesis, ectopic migration of dentate granule cells (DGCs), and hilar cell death after seizures, which may contribute to the generalized seizure-resistant phenotype of FGF22KO mice
	potentially involved in midbrain development downstream of FGF3 and FGF8 in the midbrain-hindbrain boundary (MHB) but not of Hh in the floor plate
	FGF22 and FGF7 are postsynaptic-cell-derived presynaptic organizers necessary for excitatory and inhibitory presynaptic differentiation, respectively, in the hippocampus

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurology epilepsy   inhibition of FGF22 may alleviate epileptogenesis

ANIMAL & CELL MODELS

Fgf22 knockout (KO) mice show resistance to generalized seizures in adults as assessed by chemical kindling