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FLASH GENE

Symbol

FGF20

contributors: mct/npt - updated : 11-03-2008

HGNC name	fibroblast growth factor 20
HGNC id	3677

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	8p22      Physical location : 16.850.333 - 16.859.674
Synonym symbol(s)	FGF-20

DNA

TYPE	functioning gene
STRUCTURE	9.34 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_019851 3 - 1016 NP_062825 - 211 - Satake (2007)

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine         Nervous brain         Visual eye

cell lineage
cell lines	colon cancer cell lines
fluid/secretion

at STAGE

physiological period

fetal

Text	low level in fetal liver, brain, kidney, fetal eye anterior segment, retina, RPE, choroid

PROTEIN

PHYSICAL PROPERTIES		Hydrophobic
STRUCTURE

motifs/domains	a weak hydrophobic region at the N terminus
	a strong hydrophobic region in the FGF core domain

HOMOLOGY

interspecies

homolog to xenopus fgf20

intraspecies

homolog to FGF9,FGF16

Homologene

FAMILY	heparin binding growth factor family
	FGF9 subfamily

CATEGORY

signaling growth factor

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	involved in embnryonic development cell growth, morphogenesis, tissue repair, tumor invasion and growth
	having neurotrophic properties and promotes survival of dopaminergic neurons
	homodimerization controls the binding to the receptor and heparan sulfate-dependent diffusion in the extracellular matrix (Kalinina 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

for Parkinson's disease (associated with PD synergistically with SNCA)

Variant & Polymorphism other	increasing the risk of Parkinson's disease

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS