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FLASH GENE
Symbol FGF20 contributors: mct/npt - updated : 11-03-2008
HGNC name fibroblast growth factor 20
HGNC id 3677
Location 8p22      Physical location : 16.850.333 - 16.859.674
Synonym symbol(s) FGF-20
DNA
TYPE functioning gene
STRUCTURE 9.34 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
SGCZ 8p22 sarcoglycan zeta N33 8p22 sarcoglycan zeta LOC137012 8p22 protein phosphatase 1A pseudogene LOC392202 8 similar to 60S ribosomal protein L32 MSR1 8p22 macrophage scavenger receptor 1 LOC392203 8 similar to matricin MRPL49P2 8p22 similar to matricin FGF20 8p22-p21.3 fibroblast growth factor 20 LOC286097 8p22 hypothetical protein LOC286097 ZDHHC2 8p21.3-p22 zinc finger, DHHC domain containing 2 CNOT7 8p22-p21.3 CCR4-NOT transcription complex, subunit 7 FLJ32642 8p22 hepatocellular carcinoma related protein 1 MTMR7 8p22 myotubularin related protein 7 LOC392204 8 similar to ADAM 25 precursor (A disintegrin and metalloproteinase domain 25) (Testase 2) SLC7A2 8p22-p21.3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 PDGFRL 8p22-p21.3 platelet-derived growth factor receptor-like MTSG1 8p22 mitochondrial tumor suppressor gene 1 LOC389636 8 LOC389636 FGL1 8p22-p21.3 fibrinogen-like 1 PCM1 8p22-p21.3 pericentriolar material 1 ASAH1 8p22-p21.3 N-acylsphingosine amidohydrolase (acid ceramidase) 1 MRPS18CP3 8p21.3 mitochondrial ribosomal protein S18C pseudogene 3 UNQ9391 8p23.1 tryptophan/serine protease NAT1 8p22 N-acetyltransferase 1 (arylamine N-acetyltransferase) LOC392205 8 similar to acetyltransferase LOC392206 8 similar to ribosomal protein L10a NAT2 8p22 N-acetyltransferase 2 (arylamine N-acetyltransferase) DKFZp761K1423 8p22 hypothetical protein DKFZp761K1423 EFA6R 8pter-p23.3 hypothetical protein DKFZp761K1423 LOC389637 8 LOC389637 LOC389638 8 LOC389638 LOC392207 8 similar to PMCA2av FLJ20967 8p21.2 hypothetical protein FLJ20967 ChGn 8p21.3 chondroitin beta1,4 N-acetylgalactosaminyltransferase FLJ10569 8p21.3 hypothetical protein FLJ10569
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 1016 - 211 - Satake (2007)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine    
Nervousbrain    
Visualeye    
cell lineage
cell lines colon cancer cell lines
fluid/secretion
at STAGE
physiological period fetal
Text low level in fetal liver, brain, kidney, fetal eye anterior segment, retina, RPE, choroid
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • a weak hydrophobic region at the N terminus
  • a strong hydrophobic region in the FGF core domain
  • HOMOLOGY
    interspecies homolog to xenopus fgf20
    intraspecies homolog to FGF9,FGF16
    Homologene
    FAMILY
  • heparin binding growth factor family
  • FGF9 subfamily
  • CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • involved in embnryonic development cell growth, morphogenesis, tissue repair, tumor invasion and growth
  • having neurotrophic properties and promotes survival of dopaminergic neurons
  • homodimerization controls the binding to the receptor and heparan sulfate-dependent diffusion in the extracellular matrix (Kalinina 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • for Parkinson's disease (associated with PD synergistically with SNCA)
  • Variant & Polymorphism other increasing the risk of Parkinson's disease
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS