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FLASH GENE
Symbol FGF16 contributors: mct - updated : 17-12-2014
HGNC name fibroblast growth factor 16
HGNC id 3672
Corresponding disease
MCPF4 metacarpal 4-5 fusion
Location Xq21.1      Physical location : 76.709.646 - 76.712.011
Synonym symbol(s) FGF-16
DNA
TYPE functioning gene
STRUCTURE 2.37 kb     2 Exon(s)
regulatory sequence Promoter (TATA box)
Binding site   enhancer
text structure
  • a putative myocyte enhancer factor 2 (MEF2)-binding site at nucleotides -1159/-1148, and chromatin remodeling and MEF2 binding in the FGF16 promoter contribute to expression in the postnatal heart
  • TATA1 and the proximal NF-kappaB element are conserved in the human genome
  • promoter possesses the binding elements of PITX2 as well as T-cell factor (Wnt-responsive)
  • MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 624 23.6 207 - 2006 16756958
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   predominantly Homo sapiens
    Reproductivefemale systemovary  highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose   
    Muscularstriatumcardiacmyocardium  Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to rattus Fgf16 (98.6 pc)
    ortholog to murine Fgf16 (99.5 pc)
    Homologene
    FAMILY
  • heparin-binding growth factors family
  • FGF9 subfamily
  • CATEGORY enzyme , signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • inducing hepatocellular proliferation
  • may be playing a role in proliferation of embryonic brown adipose tissue
  • enhancing cell migration in response to mechanical damage
  • required for embryonic heart development in mid-gestation through its positive effect on myocardial growth
  • is required for embryonic heart development in mid-gestation through its positive effect on myocardial growth
  • is a target for NF-kappaB activation in the postnatal heart
  • in conjunction with Wnt pathway contributes to the cancer phenotype of ovarian cells
  • CELLULAR PROCESS cell life, antiapoptosis
    cell migration & motility
    PHYSIOLOGICAL PROCESS development , active transport
    text
  • mitogenesis, cell growth
  • organ morphogenesis
  • PATHWAY
    metabolism
    signaling signal transduction
  • cell-cell signaling
  • fibroblast growth factor receptor signaling pathway
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FGF16 prevents potentially angiotensin II-induced cardiac hypertrophy and fibrosis by antagonizing FGF2
  • PITX2 homeodomain transcription factor interacts with and regulates FGF16 expression
  • cell & other
    REGULATION
    Other response to temperature stimulus
    ASSOCIATED DISORDERS
    corresponding disease(s) MCPF4
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    modulation of its expression in ovarian cells might be a promising therapeutic strategy for the treatment of invasive ovarian cancers
    ANIMAL & CELL MODELS