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FLASH GENE
Symbol FGD6 contributors: - updated : 07-06-2005
HGNC name FYVE, RhoGEF and PH domain containing 6
HGNC id 21740
Location 12q22      Physical location : 95.470.525 - 95.611.240
Synonym symbol(s) ZFYVE24
DNA
TYPE functioning gene
STRUCTURE 138.00 kb     21 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   highly
Digestivemouthtongue  highly
Lymphoid/Immunelymph node   predominantly
Reproductivefemale systemuteruscervix highly
 female systembreastmammary gland moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Fgd6
Homologene
FAMILY
CATEGORY regulatory , structural protein
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,Golgi
intracellular,cytoplasm,cytoskeleton
text lamellipodium and ruffle
basic FUNCTION
  • acting as a guanyl-nucleotide exchange factor
  • involved in actin cytoskeleton organization and biogenesis
  • playing a role filopodium formation
  • involved in regulation of cell shape
  • CELLULAR PROCESS cell life, proliferation/growth
    cell organization/biogenesis
    cell migration & motility
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS