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FLASH GENE
Symbol FGD5 contributors: - updated : 08-06-2006
HGNC name FYVE, RhoGEF and PH domain containing 5
HGNC id 19117
Location 3p25.1      Physical location : 14.860.468 - 14.976.071
Synonym name zinc finger FYVE domain-containing protein 23
Synonym symbol(s) ZFYVE23
DNA
TYPE functioning gene
STRUCTURE 115.00 kb     20 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text umbilical cord, highly
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one DH (DBL-homology) domain
  • one FYVE-type zinc finger
  • two PH domains
  • HOMOLOGY
    interspecies homolog to murine Fgd5 (79.3pc)
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • may activate CDC42 by exchanging bound GDP for free GTP
  • may play a role in regulating the actin cytoskeleton and cell shape
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • ion Zn2+ binding
  • GTP binding
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS