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FLASH GENE
Symbol FGD3 contributors: mct/npt - updated : 16-02-2009
HGNC name FYVE, RhoGEF and PH domain containing 3
HGNC id 16027
Location 9q22      Physical location : 95.709.600 - 95.798.518
Synonym name
  • faciogenital dysplasia homolog 3
  • FGD1 family, member 3
  • Rho GEF (guanine nucleotide exchange factor) 3
  • zinc finger FYVE domain-containing protein 5
  • Synonym symbol(s) FLJ00004, ZFYVE5, MGC117260
    DNA
    TYPE functioning gene
    STRUCTURE 88.92 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC347318 9q22.31 similar to 60S ribosomal protein L21 SPTLC1 9q22.1-q22.2 serine palmitoyltransferase, long chain base subunit 1 LOC389772 9 similar to Osteotesticular phosphatase; protein tyrosine phosphatase, receptor type, V LOC392368 9 similar to KIAA1553 protein LOC138652 9q22.32 similar to bA62C3.1 (similar to testicular serine protease) IARS 9q21 isoleucine-tRNA synthetase C9orf34 9q22.32 chromosome 9 open reading frame 34 OGN 9q22.3 osteoglycin (osteoinductive factor, mimecan) OMD 9p22.3 osteomodulin ASPN 9q22-q31 asporin (LRR class 1) ECM2 9q22.3 extracellular matrix protein 2, female organ and adipocyte specific C9orf12 9q21.33-q22.31 chromosome 9 open reading frame 12 BICD2 9q22.1-q22.3 chromosome 9 open reading frame 12 ANKRD19 9q22.32 ankyrin repeat domain 19 BA526D8.4 9q22.32 KRAB box containing C2H2 type zinc finger bA526D8.4 LOC389773 9 LOC389773 LOC340518 9q22.32 similar to Alox15 protein FGD3 9q22 FGD1 family, member 3 MGC26847 LOC389774 9 LOC389774 MGC11115 9q22.32 hypothetical protein MGC11115 LOC389775 9 LOC389775 NINJ1 9q22.3 ninjurin 1 PRKWNK2 9q22.3 protein kinase, lysine deficient 2 C9orf10OS 9q22.32 chromosome 9 open reading frame 10 opposite strand C9orf10 9q22.31 chromosome 9 open reading frame 10 PHF2 9q22.31 PHD finger protein 2 BARX1 9q12 BarH-like homeobox 1 PTP9Q22 9q22.32 protein tyrosine phosphatase PTP9Q22 HCP24 9q22.32 cytochrome c, somatic pseudogene
    RNA
    TRANSCRIPTS type messenger
    text variants 1 and 2 encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 3470 79.3 725 - Humphray (2004)
    18 - 3370 79.3 725 - Humphray (2004)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Reproductivemale systemprostate   
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a Rho GEF (DBL) domain
  • multiple phosphoinositide-binding domains
  • a pleckstrin homology domain (PH)
  • a distinctive FYVE domain
  • a second C terminal PH domain
  • HOMOLOGY
    interspecies ortholog to murine Fgd3
    Homologene
    FAMILY
  • FGD1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • modulate the actin cytoskeleton, being Cdc42-specific exchange factors (Huber 2008)
  • likely couple the actin cytoskeleton with the plasma membrane (Nakanishi 2008)
  • with FGD1 play different roles to regulate cellular functions but their intracellular levels are tightly controlled by the same destruction pathway through SCF(FWD1/beta-TrCP) (Hayakawa 2008)
  • CELLULAR PROCESS protein
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS