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FLASH GENE
Symbol FGD2 contributors: mct - updated : 06-01-2011
HGNC name FYVE, RhoGEF and PH domain containing 2
HGNC id 3664
Location 6p21.2      Physical location : 36.973.422 - 36.996.845
Synonym name
  • FGD1 family, member 2
  • Rho GEF (guanine nucleotide exchange factor) 2
  • FLJ00276 protein
  • Synonym symbol(s) MGC71330, ZFYVE4, FLJ00276, MGC71330, FLJ00048, C21orf61, FLJ40929, MRAP, GCCD2, FALP
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head
    STRUCTURE 23.42 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 3045 - 655 - 2007 17564959
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node    
     spleen    
     thymus    
     tonsils    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell Homo sapiens
    Lymphoid/Immunedendritic cell Homo sapiens
    Lymphoid/Immunemacrophage Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • adjacent RhoGEF and PH domains
  • a second carboxy-terminal PH domain
  • a distinctive FYVE domain, conserved domain for endosomal localization
  • C-terminal pleckstrin homology domain mediates recruitment to membrane ruffles
  • HOMOLOGY
    intraspecies homolog to FGD1
    Homologene
    FAMILY
  • small subfamily of predicted RhoGEFs
  • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytoskeleton,microfilament
    text complex intracellular localization, with concentrations found in membrane ruffles and early endosomes, sole member of the characterized Fgd family that can localize to early endocytic vesicles
    basic FUNCTION
  • may be playing a role in embryonic development
  • playing a role in leukocyte signaling and vesicle trafficking in cells specialized to present antigen in the immune system
  • may have a role in the regulation of cell polarization and migration, since membrane ruffles often form at the leading edge of migrating cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • role of FGD2 in the activation of Cdc42 and not of Rac1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS