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FLASH GENE
Symbol FGB contributors: mct/npt - updated : 30-06-2009
HGNC name fibrinogen beta chain
HGNC id 3662
Corresponding disease
CAFG congenital afibrinogenemia
TRDF thrombosis, recurrent, dysfibrinogenemic type (fibrinogen A, B or G defect)
Location 4q32.1      Physical location : 155.484.131 - 155.493.915
Synonym name fibrinogen, B beta polypeptide
Synonym symbol(s) MGC104327, MGC120405
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text see FG@
STRUCTURE 8.11 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
Map cen - FGG - FGA - FGB - qter
Authors Aschbacher et al.(85)
Physical map
LOC389232 4 LOC389232 LOC389233 4 LOC389233 FBXW7 4q31.23 F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila) LOC391706 4 similar to ribosomal protein S3a; 40S ribosomal protein S3a; v-fos transformation effector protein 1 FLJ32028 4q31.3 hypothetical protein FLJ32028 TIGD4 4q31.23 tigger transposable element derived 4 ARFIP1 4q31.3 ADP-ribosylation factor interacting protein 1 (arfaptin 1) LOC152667 4q31.3 similar to NEFA-interacting nuclear protein NIP30 KIAA1727 4q31.3 KIAA1727 protein LOC389234 4 LOC389234 TRIM2 4q31.3 tripartite motif-containing 2 ANXA2P1 4q21-q31 annexin A2 pseudogene 1 GAJ 4q31.3 GAJ protein KIAA0922 4q31.23 GAJ protein LOC285532 4q31.3 similar to JM5 protein TLR2 4q32 toll-like receptor 2 LOC285533 4q31.3 hypothetical protein LOC285533 SFRP2 4q31.3 secreted frizzled-related protein 2 FLJ20047 4q31.3 hypothetical protein FLJ20047 LOC389235 4 similar to protocadherin 16 precursor; fibroblast cadherin FIB1; fibroblast cadherin 1; dachsous homologue PLRG1 4q31.2-q32.1 pleiotropic regulator 1 (PRL1homolog, Arabidopsis) FGB 4q28 fibrinogen, B beta polypeptide FGA 4q28 fibrinogen, A alpha polypeptide FGG 4q28 fibrinogen, G gamma polypeptide LRAT 4q31.1-q31.23 lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) MGC27016 4q31.3 hypothetical protein MGC27016 LOC389236 4 LOC389236 NPY2R 4q31 neuropeptide Y receptor Y2 LOC389237 4 LOC389237 FLJ21159 4q31.3 hypothetical protein FLJ21159 GUCY1A3 4q31.1-q31.2 guanylate cyclase 1, soluble, alpha 3 GUCY1B3 4q31.3-q33 guanylate cyclase 1, soluble, beta 3 ACCN5 4q31.3-q32 amiloride-sensitive cation channel 5, intestinal TDO2 4q31-q32 tryptophan 2,3-dioxygenase CTSO 4q31-q32 cathepsin O FTHP2 4q31-q32 ferritin, heavy polypeptide pseudogene 2 PDGFC 4q32 platelet derived growth factor C GLRB 4q31.3 glycine receptor, beta LOC391707 4 similar to Chromatin accessibility complex protein 1 (CHRAC-1) (CHRAC-15) (HuCHRAC15) (DNA polymerase epsilon subunit p15) GRIA2 4q32-q33 glutamate receptor, ionotropic, AMPA 2
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1963 52.3 491 - Marx (2004)
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
Cardiovascularheart   highly
Digestiveliver   highly
Endocrinepancreas    
Nervousbrain   highly
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion plasma
at STAGE
physiological period embryo, fetal
Text liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal fibrinopeptide
  • a region participating in disulfide ring and coiled-coil formation
  • an apparent globular domain
  • a unique site of N-glycosylation
  • the C-terminal sequences having a role in fibrin(ogen) polymerization as well as in cell attachment (Marx 2004)
    • conjugated GlycoP
    mono polymer heteromer , hexamer
    isoforms Precursor cleaved by thrombin in the N-terminal region to form fibrin which is the most abundant component of blood clots
    HOMOLOGY
    interspecies ortholog to murine Fgb
    homolog to C.elegans C55B6.2
    Homologene
    FAMILY
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • playing a role in blood clotting and other responses to injury
  • acting as a cofactor platelet aggregation
  • regulating cell adhesion and spreading (various cleavage products of fibrinogen and fibrin)
  • displaying vasoconstrictor and chemotactic activities (various cleavage products of fibrinogen and fibrin)
  • playing a role in regulation of blood pressure
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS coagulation/hemostasis
    text positive regulation of cell proliferation
    PATHWAY
    metabolism
    signaling
    a component
  • fibrinogen, dimeric protein consisting of six chains (alpha 2, beta 2, gamma 2) held together by disulfide bonds
  • beta subunit of fibrinogen
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CAFG , TRDF
    related resource A Database For Human Fibrinogen Variants
    Susceptibility
  • to thromboembolic diseases
  • to non-fatal acute MI
  • to recurrent pregnancy loss
    • Variant & Polymorphism SNP
  • beta-fibrinogen -455G>A influencing susceptibility to thromboembolic diseases (Hoppe 2006)
  • the G-455A polymorphism has a "protective effect" against the development of non-fatal acute MI
  • 455G>A, can identify individuals at risk for recurrent pregnancy loss (Goodman 2006)
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS