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FLASH GENE
Symbol FGB contributors: mct/npt - updated : 30-06-2009
HGNC name fibrinogen beta chain
HGNC id 3662
Corresponding disease
CAFG congenital afibrinogenemia
TRDF thrombosis, recurrent, dysfibrinogenemic type (fibrinogen A, B or G defect)
Location 4q32.1      Physical location : 155.484.131 - 155.493.915
Synonym name fibrinogen, B beta polypeptide
Synonym symbol(s) MGC104327, MGC120405
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text see FG@
STRUCTURE 8.11 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
Map cen - FGG - FGA - FGB - qter
Authors Aschbacher et al.(85)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1963 52.3 491 - Marx (2004)
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
Cardiovascularheart   highly
Digestiveliver   highly
Endocrinepancreas    
Nervousbrain   highly
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion plasma
at STAGE
physiological period embryo, fetal
Text liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal fibrinopeptide
  • a region participating in disulfide ring and coiled-coil formation
  • an apparent globular domain
  • a unique site of N-glycosylation
  • the C-terminal sequences having a role in fibrin(ogen) polymerization as well as in cell attachment (Marx 2004)
  • conjugated GlycoP
    mono polymer heteromer , hexamer
    isoforms Precursor cleaved by thrombin in the N-terminal region to form fibrin which is the most abundant component of blood clots
    HOMOLOGY
    interspecies ortholog to murine Fgb
    homolog to C.elegans C55B6.2
    Homologene
    FAMILY
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • playing a role in blood clotting and other responses to injury
  • acting as a cofactor platelet aggregation
  • regulating cell adhesion and spreading (various cleavage products of fibrinogen and fibrin)
  • displaying vasoconstrictor and chemotactic activities (various cleavage products of fibrinogen and fibrin)
  • playing a role in regulation of blood pressure
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS coagulation/hemostasis
    text positive regulation of cell proliferation
    PATHWAY
    metabolism
    signaling
    a component
  • fibrinogen, dimeric protein consisting of six chains (alpha 2, beta 2, gamma 2) held together by disulfide bonds
  • beta subunit of fibrinogen
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CAFG , TRDF
    related resource A Database For Human Fibrinogen Variants
    Susceptibility
  • to thromboembolic diseases
  • to non-fatal acute MI
  • to recurrent pregnancy loss
  • Variant & Polymorphism SNP
  • beta-fibrinogen -455G>A influencing susceptibility to thromboembolic diseases (Hoppe 2006)
  • the G-455A polymorphism has a "protective effect" against the development of non-fatal acute MI
  • 455G>A, can identify individuals at risk for recurrent pregnancy loss (Goodman 2006)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS