Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | FGB | contributors: mct/npt - updated : 30-06-2009 |
HGNC name | fibrinogen beta chain |
HGNC id | 3662 |
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Corresponding disease |
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Location | 4q32.1 Physical location : 155.484.131 - 155.493.915 | ||||
Synonym name | fibrinogen, B beta polypeptide | ||||
Synonym symbol(s) | MGC104327, MGC120405 |
DNA |
TYPE | functioning gene |
SPECIAL FEATURE | component of a cluster |
text | see FG@ |
STRUCTURE | 8.11 kb 8 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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MAPPING | cloned | Y | linked | Y | status | confirmed |
Map | cen - FGG - FGA - FGB - qter |
Authors | Aschbacher et al.(85) |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type |
constitutive of |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
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tissue |
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cell lineage
cell lines
| fluid/secretion
| plasma | |
at STAGE |
physiological period | embryo, fetal |
Text | liver |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
| |
conjugated | GlycoP |
mono polymer | heteromer , hexamer |
isoforms | Precursor | cleaved by thrombin in the N-terminal region to form fibrin which is the most abundant component of blood clots |
HOMOLOGY |
interspecies | ortholog to murine Fgb |
homolog to C.elegans C55B6.2 |
Homologene |
FAMILY |
CATEGORY | adhesion |
SUBCELLULAR LOCALIZATION | extracellular |
basic FUNCTION | |
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CELLULAR PROCESS | cell life, proliferation/growth |
PHYSIOLOGICAL PROCESS | coagulation/hemostasis |
text | positive regulation of cell proliferation |
PATHWAY |
metabolism |
signaling |
a component | |
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INTERACTION |
DNA |
RNA |
small molecule |
protein |
cell & other |
REGULATION |
ASSOCIATED DISORDERS |
corresponding disease(s) | CAFG , TRDF |
related resource | A Database For Human Fibrinogen Variants |
Susceptibility |
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Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |