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FLASH GENE
Symbol FGA contributors: npt/ - updated : 24-04-2006
HGNC name fibrinogen alpha chain
HGNC id 3661
Corresponding disease
CAFG congenital afibrinogenemia
FAMYR1 familial amyloidosis, Ostertag type
TRDF thrombosis, recurrent, dysfibrinogenemic type (fibrinogen A, B or G defect)
Location 4q32.1      Physical location : 155.504.279 - 155.511.897
Synonym name
  • fibrinogen, A alpha polypeptide
  • fibrinogen, alpha chain, isoform alpha preproprotein
  • Synonym symbol(s) Fib2, MGC119422, MGC119423, MGC119425
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text see FG@
    STRUCTURE 7.62 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Map cen - FGG - FGA - FGB - qter
    Authors Aschbacher (1985)
    Physical map
    LOC389232 4 LOC389232 LOC389233 4 LOC389233 FBXW7 4q31.23 F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila) LOC391706 4 similar to ribosomal protein S3a; 40S ribosomal protein S3a; v-fos transformation effector protein 1 FLJ32028 4q31.3 hypothetical protein FLJ32028 TIGD4 4q31.23 tigger transposable element derived 4 ARFIP1 4q31.3 ADP-ribosylation factor interacting protein 1 (arfaptin 1) LOC152667 4q31.3 similar to NEFA-interacting nuclear protein NIP30 KIAA1727 4q31.3 KIAA1727 protein LOC389234 4 LOC389234 TRIM2 4q31.3 tripartite motif-containing 2 ANXA2P1 4q21-q31 annexin A2 pseudogene 1 GAJ 4q31.3 GAJ protein KIAA0922 4q31.23 GAJ protein LOC285532 4q31.3 similar to JM5 protein TLR2 4q32 toll-like receptor 2 LOC285533 4q31.3 hypothetical protein LOC285533 SFRP2 4q31.3 secreted frizzled-related protein 2 FLJ20047 4q31.3 hypothetical protein FLJ20047 LOC389235 4 similar to protocadherin 16 precursor; fibroblast cadherin FIB1; fibroblast cadherin 1; dachsous homologue PLRG1 4q31.2-q32.1 pleiotropic regulator 1 (PRL1homolog, Arabidopsis) FGB 4q28 fibrinogen, B beta polypeptide FGA 4q28 fibrinogen, A alpha polypeptide FGG 4q28 fibrinogen, G gamma polypeptide LRAT 4q31.1-q31.23 lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) MGC27016 4q31.3 hypothetical protein MGC27016 LOC389236 4 LOC389236 NPY2R 4q31 neuropeptide Y receptor Y2 LOC389237 4 LOC389237 FLJ21159 4q31.3 hypothetical protein FLJ21159 GUCY1A3 4q31.1-q31.2 guanylate cyclase 1, soluble, alpha 3 GUCY1B3 4q31.3-q33 guanylate cyclase 1, soluble, beta 3 ACCN5 4q31.3-q32 amiloride-sensitive cation channel 5, intestinal TDO2 4q31-q32 tryptophan 2,3-dioxygenase CTSO 4q31-q32 cathepsin O FTHP2 4q31-q32 ferritin, heavy polypeptide pseudogene 2 PDGFC 4q32 platelet derived growth factor C GLRB 4q31.3 glycine receptor, beta LOC391707 4 similar to Chromatin accessibility complex protein 1 (CHRAC-1) (CHRAC-15) (HuCHRAC15) (DNA polymerase epsilon subunit p15) GRIA2 4q32-q33 glutamate receptor, ionotropic, AMPA 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 2110 67.7 644 - Dixon
    exon 1-5
    6 splicing 3655 93 866 - Fuy
    extrasequence of exon 6 enhanced by IL6
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Lymphoid/Immunespleen    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver
    IMPRINTING paternally
    text paternally imprinted in any cases of a fibrinogenemia
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal fibrinopeptide removed by thrombin during the conversion of fibrinogen to fibrin
  • a coiled-coil domain and the associated flanking disulfide bonds with beta and gamma
  • a RGD sequence in the middle chain
  • a region of high proline content,then a region exeptionally rich in glycine,serine,threonine,proline and tryptophan residues forming eight tandem repeats
  • an hydrophilic C terminus including another RGD sequence
  • isoforms Precursor cleaved by thrombin in the N terminal region
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
    text plasma
    basic FUNCTION
  • having a double function : yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS coagulation/hemostasis
    PATHWAY
    metabolism
    signaling
    a component
  • fibrinogen, dimeric protein consisting of six chains (alpha 2, beta 2, gamma 2) held together by disulfide bonds
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) FAMYR1 , CAFG , TRDF
    related resource A Database For Human Fibrinogen Variants
    Susceptibility to venous thromboembolism
    Variant & Polymorphism other polymorphism associated to venous thromboembolism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS