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FLASH GENE
Symbol FEZF2 contributors: mct - updated : 10-09-2015
HGNC name FEZ family zinc finger 2
HGNC id 13506
Location 3p14.2      Physical location : 62.355.346 - 62.359.190
Synonym name
  • forebrain embryonic zinc finger-like gene
  • too few, zebrafish homolog
  • zinc finger protein 312
    • Synonym symbol(s) FEZL, FKSG36, FLJ10142, Fez, TOF, ZFP312, ZNF312
    DNA
    TYPE functioning gene
    STRUCTURE 3.84 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2095 48 459 - 2011 21471212
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainforebraincerebral cortex  
    Visualeye    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervouspyramidal cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text early during embryonic development, ventricular zone progenitor cells
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal domain with homology to the canonical engrailed repressor motif
  • a KRAB domain
  • C-terminal DNA binding domain containing six C2H2 zinc-finger repeats
    • HOMOLOGY
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    basic FUNCTION
  • transcriptional repressor, required for the differentiation of projection neurons in cortical layer 5
  • is essential for specification of the subcerebral projection neurons in the neocortex
  • FEZF1 and FEZF2 control likely the rostro-caudal patterning of the diencephalon
  • FEZF1 and FEZF2 bind to and directly repress the promoter activity of HES5
  • FEZF1 and FEZF2 control differentiation of neural stem cells by repressing HES5 and, in turn, by derepressing neurogenin 2 in the forebrain
  • playing a critical role in layer- and neuronal subtype-specific patterning of cortical axonal projections and dendritic morphologies
  • required for the birth and specification of corticospinal motor neurons
  • directs the differentiation of corticofugal neurons from striatal progenitors
  • conserved gene critical for vertebrate forebrain development
  • FEZF1 and FEZF2, regulate the identity of main olfactory epithelium (MOE) sensory neurons and are essential for the survival of vomeronasal organ (VNO), neurons respectively
  • is important for early development of the posterior hypothalamus
  • is required for the development of excitatory neurons and nuclear morphology in the lateral and basolateral nuclei
  • FEZF1 and FEZF2 as important regulators of olfactory system development and sensory neuron identity
  • controlling neurogenesis and cell fate in the developing mammalian nervous system
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BCL11B is a major downstream effector of FEZF2 in regulating the extension of axons toward subcortical targets and can rescue the axonal phenotype of FEZF2 mutants
  • TBR1 is a direct transcriptional repressor of FEZF2 and a negative regulator of corticospinal tract formation that restricts the laminar origin of corticospinal axons specifically to L5
  • axon guidance receptor EPHB1 is a target of FEZF2 necessary to execute the ipsilateral extension of the corticospinal tract
    • cell & other
    REGULATION
    Other regulated by SOX5 and TBR1 (both SOX5 and TBR1 are required in the regulation of FEZF2 transcription)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • candidate for evaluation in human microcephaly
    • Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Fezf2(-/-) neurons adopt the fate of callosal projection neurons as assessed by their axonal projections, electrophysiological properties, and acquisition of Satb2 expression