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FLASH GENE
Symbol FEZ1 contributors: mct - updated : 30-05-2015
HGNC name fasciculation and elongation protein zeta 1 (zygin I)
HGNC id 3659
Location 11q24.2      Physical location : 125.315.640 - 125.366.206
Synonym name zygin I
DNA
TYPE functioning gene
STRUCTURE 50.47 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 1702 45 392 - 1997 9096408
also called FEZ1L
2 - 1753 - 104 - 1997 9096408
also called FEZ1T (short form)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestivepharynx   highly
Endocrineparathyroid   highly
Nervousbrain   highly Homo sapiens
Visualeye   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • N terminus, highly acidic, coiled coil domain
  • four coiled-coiled domains
  • a nuclear localization signal
    • HOMOLOGY
    interspecies ortholog to C.elegans Unc76
    intraspecies homolog to FEZ2
    Homologene
    FAMILY
  • zygin family
    • CATEGORY regulatory , structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    basic FUNCTION
  • playing a role in axonal outgrowth and fasciculation
  • participating in the establishment of neuronal polarity by controlling the mitochondrial motility along axon
  • participate in the development of the central nervous system during mammalian embryogenesis
  • essential for the establishment of neuronal polarity by controlling the mitochondrial transport in hippocampal neurons
  • neuronal protein that influences axonal development and cell polarization
  • is associated with neuronal development, neuropathologies, and viral infection
  • may play important roles in astrocytes, and mood stabilizers might exert their cytoprotective and mood-stabilizing effects by inducing FEZ1 expression in astrocytes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • SCOC forms a complex with fasciculation and elongation protein zeta 1 (FEZ1)
  • SCOC forms a starvation-sensitive trimeric complex with UVRAG (UV radiation resistance associated gene) and FEZ1
  • dimerizes in its N-terminal region and interacts with other proteins, including the candidate cargoe proteins, through its C-terminus
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PRKCZ
  • PRKCH
  • M17S2 (NBR1)
  • interacts with kinesin superfamily protein 5 (KIF5) and tubulin
  • interacts with other proteins (SCOC), mitochondria, and vesicles
  • DISC1 and its interacting protein FEZ1 positively regulates dendrite growth in young neurons
  • CDC20/APC controls dendrite growth by regulating the degradation of FEZ1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in the brain tissue from schizophrenia
    Susceptibility schizophrenia
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS