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FLASH GENE
Symbol FEZ1 contributors: mct - updated : 30-05-2015
HGNC name fasciculation and elongation protein zeta 1 (zygin I)
HGNC id 3659
Location 11q24.2      Physical location : 125.315.640 - 125.366.206
Synonym name zygin I
DNA
TYPE functioning gene
STRUCTURE 50.47 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC390272 11 similar to seven transmembrane helix receptor LOC283162 11q24.2 similar to Olfactory receptor 8B4 OR8B8 11q24.2 olfactory receptor, family 8, subfamily B, member 8 LOC390273 11 similar to Olfactory receptor 8A1 (OST025) OR8B9P 11q25 olfactory receptor, family 8, subfamily B, member 9 pseudogene LOC390274 11 similar to olfactory receptor MOR161-5 LOC219858 11q24.2 similar to Olfactory receptor 8B12 LOC390275 11 similar to Olfactory receptor 8A1 (OST025) PANX3 11q24.2 pannexin 3 TBRG1 11q24.2 likely ortholog of mouse transforming growth factor beta regulated gene 1 CSE-C 11q24 cytosolic sialic acid 9-O-acetylesterase homolog SPA17 11q24.2 sperm autoantigenic protein 17 NRGN 11q24 neurogranin (protein kinase C substrate, RC3) CTXL 11q24 cortical thymocyte receptor (X. laevis CTX) like ESAM 11q24.2 cortical thymocyte receptor (X. laevis CTX) like FLJ23342 11q24.2 hypothetical protein FLJ23342 RBIG1 11q24.2 retinoblastoma inhibiting gene 1 ROBO4 11q24.2 roundabout homolog 4, magic roundabout (Drosophila) FLJ25530 11q24.2 hypothetical protein FLJ25530 FLJ13215 11q24.2 hypothetical protein FLJ13215 LOC387816 11 similar to hypothetical protein SLC37A2 11q24.2 solute carrier family 37 (glycerol-3-phosphate transporter), member 2 LOC219854 11q24.2 hypothetical protein LOC219854 LOC390276 11 hypothetical gene supported by AK128036 LOC387817 11 LOC387817 PKNOX2 11q24 PBX/knotted 1 homeobox 2 FLJ30719 11q24.2 hypothetical protein FLJ30719 FEZ1 11q23.3-q24.2 fasciculation and elongation protein zeta 1 (zygin I) EI24 11q23-q24 etoposide induced 2.4 mRNA ITM1 11q23.3-q24.2 integral membrane protein 1 CHEK1 11q24 CHK1 checkpoint homolog (S. pombe) ACRV1 11p12-q13 acrosomal vesicle protein 1 PATE 11q24.2 acrosomal vesicle protein 1 FLJ32915 11q24.2 hypothetical protein FLJ32915 FKSG32 11q24.2 hypothetical protein FKSG32 DDX25 11q24 DEAD (Asp-Glu-Ala-Asp) box polypeptide 25 LOC338667 11q24.2 hypothetical protein LOC338667 CDON 11q23-q24 cell adhesion molecule-related/down-regulated by oncogenes LOC387818 11 similar to Nucleosome assembly protein 1-like 1 (NAP-1 related protein) (hNRP) LOC387819 11 LOC387819 FLJ14494 11q24.2 hypothetical protein FLJ14494 FLJ21103 11q24.2 hypothetical protein FLJ21103 SRPR 11q24.1 signal recognition particle receptor ('docking protein') H17 11q24.2 hypothetical protein H17 TIRAP 11q24.2 toll-interleukin 1 receptor (TIR) domain containing adaptor protein DCPS 11q24.2 mRNA decapping enzyme SIAT4C 11q23-q24 sialyltransferase 4C (beta-galactoside alpha-2,3-sialyltransferase)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 1702 45 392 - 1997 9096408
also called FEZ1L
2 - 1753 - 104 - 1997 9096408
also called FEZ1T (short form)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestivepharynx   highly
Endocrineparathyroid   highly
Nervousbrain   highly Homo sapiens
Visualeye   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • N terminus, highly acidic, coiled coil domain
  • four coiled-coiled domains
  • a nuclear localization signal
  • HOMOLOGY
    interspecies ortholog to C.elegans Unc76
    intraspecies homolog to FEZ2
    Homologene
    FAMILY
  • zygin family
  • CATEGORY regulatory , structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    basic FUNCTION
  • playing a role in axonal outgrowth and fasciculation
  • participating in the establishment of neuronal polarity by controlling the mitochondrial motility along axon
  • participate in the development of the central nervous system during mammalian embryogenesis
  • essential for the establishment of neuronal polarity by controlling the mitochondrial transport in hippocampal neurons
  • neuronal protein that influences axonal development and cell polarization
  • is associated with neuronal development, neuropathologies, and viral infection
  • may play important roles in astrocytes, and mood stabilizers might exert their cytoprotective and mood-stabilizing effects by inducing FEZ1 expression in astrocytes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • SCOC forms a complex with fasciculation and elongation protein zeta 1 (FEZ1)
  • SCOC forms a starvation-sensitive trimeric complex with UVRAG (UV radiation resistance associated gene) and FEZ1
  • dimerizes in its N-terminal region and interacts with other proteins, including the candidate cargoe proteins, through its C-terminus
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PRKCZ
  • PRKCH
  • M17S2 (NBR1)
  • interacts with kinesin superfamily protein 5 (KIF5) and tubulin
  • interacts with other proteins (SCOC), mitochondria, and vesicles
  • DISC1 and its interacting protein FEZ1 positively regulates dendrite growth in young neurons
  • CDC20/APC controls dendrite growth by regulating the degradation of FEZ1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in the brain tissue from schizophrenia
    Susceptibility schizophrenia
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS