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FLASH GENE
Symbol FER contributors: mct/npt - updated : 05-04-2008
HGNC name fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)
HGNC id 3655
Location 5q21.3      Physical location : 108.083.522 - 108.523.373
Synonym name
  • tyrosine kinase 3
  • phosphoprotein NCP94
  • Synonym symbol(s) TYK3, p94-FER, c-FER
    EC.number 2.7.10.2
    DNA
    TYPE functioning gene
    STRUCTURE 439.85 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    RAB9P1 5q14.3-q15 RAB9, member RAS oncogene family, pseudogene 1 LOC345571 5q21.3 similar to rap2 interacting protein x LOC391817 5 similar to protease (prosome, macropain) 26S subunit, ATPase 1 EFNA5 5q21 ephrin-A5 LOC391818 5 similar to Ubiquitin carboxyl-terminal hydrolase 7 (Ubiquitin thiolesterase 7) (Ubiquitin-specific processing protease 7) (Deubiquitinating enzyme 7) (Herpesvirus associated ubiquitin-specific protease) LOC345576 5q21.3 similar to Ubiquitin carboxyl-terminal hydrolase 7 (Ubiquitin thiolesterase 7) (Ubiquitin-specific processing protease 7) (Deubiquitinating enzyme 7) (Herpesvirus associated ubiquitin-specific protease) FBXO13 5q21.3 F-box only protein 13 RPS20P3 5q13-q23 ribosomal protein S20 pseudogene 3 FER 5q21 fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94) GJA1P1 5q21.3 gap junction protein, alpha 1, 43kDa (connexin 43) pseudogene 1 PJA2 5q21.1 praja 2, RING-H2 motif containing LOC391819 5 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) MAN2A1 5q21-q22 mannosidase, alpha, class 2A, member 1 LOC153778 5q22.1 hypothetical LOC153778 LOC255338 5q22.1 hypothetical LOC255338 LOC91137 5q22.2 hypothetical protein BC017169 LOC134433 5q22.2 similar to Zinc finger DHHC domain containing protein 8 (Zinc finger protein 378) LOC285639 5q22.2 similar to Bcl-2-associated transcription factor TSLP 5q22.2 thymic stromal lymphopoietin TA-WDRP 5q22.2 T-cell activation WD repeat protein LOC133744 5q22.2 similar to ribosomal protein S3a; 40S ribosomal protein S3a; v-fos transformation effector protein 1 CAMK4 5q21-q23 calcium/calmodulin-dependent protein kinase IV STARD4 5q21.3 START domain containing 4, sterol regulated C5orf13 5q22.1 chromosome 5 open reading frame 13 TIGA1 5q21-q22 TIGA1 EPB41L4A 5q22.1 erythrocyte membrane protein band 4.1 like 4A FLJ11235 5q22.2 hypothetical protein FLJ11235 APC 5q21-q22 adenomatosis polyposis coli SRP19 5q21 signal recognition particle 19kDa DP1 5q22-q23 polyposis locus protein 1 XBPP1 5q14.3-q15 X-box binding protein pseudogene 1 U2AF1L1 5q22 U2(RNU2) small nuclear RNA auxillary factor 1-like 1 DCP2 5q22.3 decapping enzyme hDcp2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 2950 - 822 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
     mouth   highly
    Lymphoid/Immunespleen   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticplatelet
    cell lineage lymphoid cells (JAK family)
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal sequences can affect their ability to induce phosphorylation of STAT3 and most probably direct different cellular functions
  • HOMOLOGY
    intraspecies homolog to fer (fps/fes related) oncogene
    Homologene
    FAMILY
  • protein kinase superfamily
  • Tyr protein kinase family
  • FPS family
  • CATEGORY enzyme , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • non receptor tyrosine kinase, required for cell-cycle progression in malignant cells
  • implicated in signaling downstream from cytokines, growth factors and immune receptors
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with NRP1 ( having a function in signaling SEMA3A-evoked neuronal death through FER in cortical neurons) (Jiang 2010)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS