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FLASH GENE
Symbol FDX1L contributors: mct - updated : 20-11-2017
HGNC name ferredoxin 1-like
HGNC id 30546
Location 19p13.2      Physical location : 10.420.890 - 10.426.691
Synonym name
  • adrenodoxin-like protein, mitochondrial
  • ferredoxin-1-like protein
  • Synonym symbol(s) MGC19604, MGC74760, FDX2
    DNA
    TYPE functioning gene
    STRUCTURE 5.80 kb     5 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 852 19.4 183 - 2012 22101253
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   moderately
    Reproductivemale systemprostate  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text predominantly in umbilical cord
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 2Fe-2S ferredoxin-type domain
  • HOMOLOGY
    interspecies ortholog to functional orthologue of yeast Yah1
    homolog to rattus Fdx1l (85.1 pc)
    homolog to murine Fdx1l (83.9 pc)
    Homologene
    FAMILY
  • adrenodoxin/putidaredoxin family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    text
  • present in the matrix of human mitochondria
  • basic FUNCTION
  • involved in electron transport chain
  • essential for Fe/S protein biogenesis in human cells and can functionally replace FDX1 (Sheftel 2010)
  • unlike FDX1, is unable to reduce mitochondrial cytochrome P450 (Sheftel 2010)
  • involved in heme A formation and Fe/S protein biogenesis, and is also essential for the maturation of cytosolic Fe/S proteins, underscoring the importance of mitochondria in all Fe/S protein production in the eukaryotic cell (Sheftel 2010)
  • is the second component of the Fe-S cluster biogenesis machinery, the first being ISCU that is associated with isolated mitochondrial myopathy
  • FDX1L, FDX1, play an important role as an electron donor in iron-sulfur (Fe-S) cluster biosynthesis
  • FDX1L, FDX1 can function in Fe-S cluster assembly
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism
    signaling
    a component
  • essential component of the Fe/S protein biogenesis pathway (Sheftel 2010)
  • INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • binding to a 2Fe-2S cluster
  • protein
  • interference with any of the three related genes, FDX1, FDX1L or FDXR, disrupts iron-sulfur cluster assembly and maintenance of normal cytosolic and mitochondrial iron homeostasis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS