Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol FCRLB contributors: npt/KTN - updated : 10/12/2008
HGNC name Fc receptor-like B
HGNC id 26431
Location 1q23.3      Physical location : 161.692.456 - 161.697.932
Synonym name
  • Fc receptor-like and mucin-like 2
  • Fc receptor homolog expressed in B cells protein 2
  • Fc receptor-related protein Y
    • Synonym symbol(s) FCRLM2, FCRL2, FREB-2, FCRLY, FCRY, FLJ31052, RP11-474I16.6
    DNA
    TYPE functioning gene
    STRUCTURE 5.48 kb     6 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    text Chikaev et al. (2005) cloned several FCRL2 splice variants
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1794 46.8 426 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth   moderately
    Lymphoid/Immunelymph node   highly
    Reproductivefemale systembreastmammary gland highly
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connective   predominantly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 17 aa hydrophobic leader peptide
  • two or three Ig-like C2-type (immunoglobulin-like) domains
  • a C-terminal domain enriched in proline, serine, and threonine
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to chimpanzee FCRLB (99.5 pc)
    homolog to cow FCRLB (88.5 pc)
    homolog to rattus Fcrlb (86.2 pc)
    homolog to murine Fcrlb (83.6 pc)
    Homologene
    FAMILY
  • immunoglobulin family
  • Fc receptor family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • may play a role in regulating clonal expansion or differentiation of B cells during the germinal center reaction
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    may be up-regulated in the progression of melanocytic tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS