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FLASH GENE
Symbol FCRLA contributors: np - updated : 15-06-2006
HGNC name Fc receptor-like A
HGNC id 18504
Location 1q23.1      Physical location : 161.676.761 - 161.684.141
Synonym name
  • Fc receptor homolog expressed in B cells
  • Fc receptor-like and mucin-like 1
  • Fc receptor-related protein X
  • Synonym symbol(s) FCRLc2, FCRLb, FCRLc1, FCRLd, FCRLe, FCRL, FREB, FCRLX, FCRLM1, MGC4595, RP11-474I16.5
    DNA
    TYPE functioning gene
    STRUCTURE 7.00 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2357 - 376 - -
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell
    Skin/Tegumentmelanocyte
    cell lineage
    cell lines
    fluid/secretion lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide
  • a hydrophilic peptide
  • two IgSF domains
  • a proline-rich region
  • a leucine-rich region
  • an endoplasmic reticulum retention signal
  • conjugated GlycoP
    mono polymer monomer , dimer
    HOMOLOGY
    interspecies homolog to murine Fcrla (71.9pc)
    Homologene
    FAMILY Fc receptor family
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • implicated in B-cell development and lymphomagenesis
  • may be having a unique role in B-cell differentiation
  • may function in melanocytes and melanoma and may be useful for development of diagnostic methods for various pigment disorders and immunotherapy of melanoma
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS