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FLASH GENE
Symbol FCRL5 contributors: mct - updated : 23-09-2013
HGNC name Fc receptor-like 5
HGNC id 18508
Location 1q23.1      Physical location : 157.483.167 - 157.522.310
Synonym name immunoglobulin superfamily receptor translocation associated 2
Synonym symbol(s) BXMAS1, IRTA2, CD307, FCRH5, PRO820, CD307e
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text component of a cluster of five IRTAs genes,contiguously located 1q21
STRUCTURE 39.14 kb     17 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 2800 82 759 - 2001 11290337
spleen,bone marow,lymphoid mode,small intestine
- - 4400 64 592 spleen, bone marow, lymph node, small intestine 2001 11290337
17 - 5395 105 977 spleen, bone marow, lymph node, small intestine 2001 11290337
  • IRTA2C
  • - - 600 16.4 152 spleen, bone marow, lymph node, small intestine 2001 11290337
    17 - 5380 - 998 - 2001 11290337
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • the three N-terminal Ig domains of FCRL5 are required for orthopoxvirus immunoevasin binding
  • eight extracellular Ig type domain
  • a cytoplasmic domain containing two ITIM domains
  • eight potential N glycosylation sites
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY Fc receptor-like (FcRL) proteins family
    CATEGORY immunity/defense , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • playing a role in regulating activation of normal B cells and possibly in the development of neoplasia
  • has the functional potential to serve as an inhibitory coreceptor on mature B cells
  • physiological role for FCRL5 in the expansion and development of antigen-primed B cells
  • may promote growth of malignant cells in hairy cell leukemia and other FCRL5-expressing tumors
  • function to costimulate or inhibit BCR signaling through consensus ITAMs and ITIMs
  • FCRL4 and FCRL5 are likely to be important for immune complex-dependent human B cell regulation
  • regulates B cell Ag receptor signaling and has been reported to bind aggregated IgG
  • new type of receptor that recognizes intact IgG, possibly enabling B cells to sense Ig quality
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
  • binds all IgG isotypes with varied efficiency
  • repressed the robust BCR activity that is characteristic of marginal zone B cells, but it had no influence on antigen receptor stimulation that is blunted in peritoneal cavity-derived B1 B cells
  • protein
  • on innate B cells is targeted by a poxvirus MHC class I-like immunoevasin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    translocation t(1;14)(q21;q32)
    tumoral       protein chimeric
    myeloma cell line with a chimeric fusion protein IRTA1/IGC alpha
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyautoimmune 
    represent novel therapeutic target for receptor blockade therapies
    ANIMAL & CELL MODELS