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FLASH GENE
Symbol FCRL4 contributors: mct - updated : 20-09-2013
HGNC name Fc receptor-like 4
HGNC id 18507
Location 1q21      Physical location : 157.543.539 - 157.567.870
Synonym name immunoglobulin superfamily receptor translocation associated 1
Synonym symbol(s) IRTA1, FCRH4, IGFP2
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text component of a cluster of five IRTAs genes, contiguously located 1q21
STRUCTURE 24.33 kb     12 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 3459 - 515 - 2002 11929751
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Lymphoid/Immunelymph node    
 tonsils    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneB cell Homo sapiens
Lymphoid/Immunelymphocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • four extracellular Ig type domains
  • three potential N glycosylation type
  • a cytoplasmic domain with three putative consensus SH2 binding domain
  • HOMOLOGY
    Homologene
    FAMILY immunoglobulin like receptor family
    CATEGORY immunity/defense , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • playing a role in regulating activation of normal B cells and possibly in the development of neoplasia
  • playing a role in the immune function of B cells within epithelia
  • may act as a molecular switch in B cells to dampen adaptive immune signaling and enhance innate signaling in response to chronic antigenic stimulation
  • function to costimulate or inhibit BCR signaling through consensus ITAMs and ITIMs
  • FCRL4 and FCRL5 are likely to be important for immune complex-dependent human B cell regulation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule other, bound efficiently to IgA
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • first positive marker for marginal zone lymphomas, enabling more accurate diagnosis of these neoplasms
  • Therapy target
    SystemTypeDisorderPubmed
    immunologyautoimmune 
    represent novel therapeutic target for receptor blockade therapies
    ANIMAL & CELL MODELS