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FLASH GENE
Symbol FCRL2 contributors: mct/npt - updated : 22/11/2008
HGNC name Fc receptor like 2
HGNC id 14875
Location 1q23.3      Physical location : 157.715.522 - 157.746.922
Synonym name
  • SH2 domain containing phosphatase anchor protein 1
  • IFGP family protein 4
    • Synonym symbol(s) FLJ31052, FREB-2, FCRH2, IFGP4, IRTA4, SPAP1, SPAP1A, SPAP1B, SPAP1C, FCRH2
    DNA
    TYPE functioning gene
    STRUCTURE 31.38 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 2573 - 255 - Kazemi (2008)
    7 - 2071 - 508 - Kazemi (2008)
    - splicing 1298 - 426 - Chikaev
    - splicing 1153 - 318 - Chikaev
    - splicing 1132 - 311 - Chikaev
    - splicing 1194 - 275 - Chikaev
    - splicing 1173 - 268 - Chikaev
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth    
    Lymphoid/Immunelymph node    
     spleen    
     thymus    
     tonsils    
    Skin/Tegumentskin    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three Ig-like domains
  • a C-terminal mucin-like domain containing a conserved alpha-helical motif with dileucine signals
    • HOMOLOGY
    intraspecies homolog to FCRL/FREB/FcRX
    Homologene
    FAMILY
  • FcR family
    • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may be up-regulated in the progression of melanocytic tumors
  • has robust predictive value for determining IGHV gene mutation status and clinical progression and thus may further improve prognostic definition in B-cell chronic lymphocytic leukemia
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    melanoma in progression
    tumoral     --other  
    in progressive and indolent clinical subtypes of B-cell chronic lymphocytic leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target potential implication of FCRL2 immunotherapeutic interventions
    ANIMAL & CELL MODELS