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FLASH GENE

Symbol

FCN3

contributors: mct/npt - updated : 07-06-2008

HGNC name	ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)
HGNC id	3625

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	FCN3D Ficolin-3 deficiency
Location	1p36.11      Physical location : 27.695.602 - 27.701.315
Synonym name	Hakata antigen
	H-ficolin
	collagen/fibrinogen domain-containing lectin 3 p35
	collagen/fibrinogen domain-containing protein 3
	ficolin 3
Synonym symbol(s)	HAKA1, FCNH, MGC22543

DNA

TYPE	functioning gene
STRUCTURE	5.00 kb     8 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 8 splicing 1059 32.9 299 - Sugimoto, Munthe-Fog (2008) variant 2 7 splicing 1026 - 288 - Sugimoto, Munthe-Fog (2008) lacking an alternate in-frame exon

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen         Digestive liver       highly Reproductive male system prostate       Respiratory lung       highly Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Digestive hepatocyte

cell lineage
cell lines
fluid/secretion	secreted into the bronchus, plasma and alveolus
	secreted into the bile duct
	present in the serum as homopolymers

at STAGE

PROTEIN

PHYSICAL PROPERTIES		basic ,fibrous
STRUCTURE

motifs/domains	a collagen-like region
	a C terminal fibrinogen-like domain

conjugated

GlycoP

mono polymer

homomer , polymer

HOMOLOGY

interspecies

homolog to Drosophila CG30281

intraspecies	homolog to FCN1
	homolog to FCN2

Homologene

FAMILY

ficolin/opsonin p35 lectin family

CATEGORY

antigen

SUBCELLULAR LOCALIZATION	extracellular
text	extracellular space, secreted

basic FUNCTION	having lectin activity
	collagen-like defence proteins that serve as recognition molecules in lectin complement pathway
	activating the complement pathway in association with MASPs and sMAP
	aiding in host defense through the activation of the lectin pathway
	has a high complement activating potential and is the only collagenase proteolytic resistant molecule among the lectin complement pathway initiators

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

lectin complement pathway

a component	homopolymer disulfide-linked
	may be an octadecamer consisting of an elementary trimer unit

INTERACTION

DNA

RNA

small molecule

protein

binding to TGF1

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

FCN3D

Susceptibility

to complement deficiency to systemic immune lupus erythematous

Variant & Polymorphism other	homozygosity for the FCN3+1637delC deletion may lead to ficolin-3 deficiency and may thus be the basis for a novel complement deficiency state

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS