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FLASH GENE

Symbol

FCN2

contributors: mct/npt - updated : 13/09/2008

HGNC name	ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)
HGNC id	3624

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	9q34.3      Physical location : 137.772.657 - 137.779.366
Synonym name	collagen/fibrinogen domain-containing protein 2
	ficolin 2
	ficolin B
	hucolin
	serum lectin p35
	37 kDa elastin-binding protein
Synonym symbol(s)	FCLNR, P35, FCNL, EBP-37

DNA

TYPE	functioning gene
STRUCTURE	6.71 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
motif	Viral sequence   gene pol
text structure	five polymorphisms in the promoter and nine in the coding region

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004108 8 splicing 1057 NP_004099 34 313 liver Endo, Hummelshoj, Garlatti (2007) also called SV0 or FCN2-A NM_015837 7 splicing 943 NP_056652 30.2 275 liver Endo, Hummelshoj, Garlatti (2007) also called SV1 or FCN2-D deletion of exon 2 reading frame unchanged

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       predominantly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage
cell lines
fluid/secretion	plasma

at STAGE

PROTEIN

PHYSICAL PROPERTIES		globular
STRUCTURE

motifs/domains	a leader peptide
	a short N-terminal segment
	a collagen-like region
	a C terminal fibrinogen-like sugar-binding domain

conjugated

GlycoP

mono polymer

homomer , polymer

HOMOLOGY

interspecies

homolog to Drosophila CG5550

intraspecies

homolog to FCN1

Homologene

FAMILY

ficolin (ficolin/opronin p35) lectin family

CATEGORY

signaling growth factor

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,cytoskeleton,intermed filament
text	secreted

basic FUNCTION	having an opsonic activity
	involved in phagocytosis of pathogens
	soluble oligomeric defence protein with lectin-like activity, assembled from collagen fibers prolonged by fibrinogen-like recognition domains
	recognizes microbial polysaccharides and glycoconjugates rich in GlcNAc or GalNAc
	may not be critical for host defence against pneumococcal infection (Chapman 2007)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

text	antimicrobial humoral response (sensu Invertebrata)

PATHWAY

metabolism

signaling

a component

homopolymer disulfide-linked

INTERACTION

DNA

RNA

small molecule	metal binding,
	Ca2+

protein

binding to TGFB1and elastin

cell & other

binding to carbohydrate

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to recurrent respiratory infections

Variant & Polymorphism SNP , other	increasing the risk of recurrent respiratory infections

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS