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FLASH GENE
Symbol FCN1 contributors: npt/ - updated : 29-06-2007
HGNC name ficolin (collagen/fibrinogen domain containing) 1
HGNC id 3623
Location 9q34.3      Physical location : 137.801.435 - 137.809.806
Synonym name
  • M-ficolin
  • ficolin-alpha
  • Synonym symbol(s) FCLN1, P35R, FCNM
    DNA
    TYPE functioning gene
    STRUCTURE 8.37 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure five polymorphisms in the promoter region
    MAPPING cloned Y linked N status confirmed
    Physical map
    ARF4P 9q34 ADP-ribosylation factor 4 pseudogene LOC158226 9q34.3 hypothetical LOC158226 RXRA 9q34.3 retinoid X receptor, alpha LOC157943 9q34.3 hypothetical LOC157943 COL5A1 9q34.3 collagen, type V, alpha 1 LOC389804 9 LOC389804 LOC392397 9 similar to hypothetical protein FCN2 9q34 ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) FCN1 9q34 ficolin (collagen/fibrinogen domain containing) 1 OLFM1 9q34.3 olfactomedin 1 LOC392398 9 similar to ligand-independent activating molecule for estrogen receptor C9orf62 9q34.3 chromosome 9 open reading frame 62 KIAA0649 9q34.3 chromosome 9 open reading frame 62 MGC29761 9q34.3 hypothetical protein MGC29761 MRPS2 9q34 mitochondrial ribosomal protein S2 LCN1 9q34 lipocalin 1 (protein migrating faster than albumin, tear prealbumin) OBP2A 9q34 lipocalin 1 (protein migrating faster than albumin, tear prealbumin) PAEP 9q34.2-q34.3 progestagen-associated endometrial protein (placental protein 14, pregnancy-associated endometrial alpha-2-globulin, alpha uterine protein) LOC138159 9q34.3 beta-lactoglobulin pseudogene GLTDC1 9q34.3 galactosyltransferase family 6 domain containing 1 LOC392399 9 similar to Putative MUP-like lipocalin precursor LOC286220 9q34.3 hypothetical protein LOC286220 KCNT1 9q34.3 potassium channel, subfamily T, member 1 CAMSAP1 9q34.3 calmodulin regulated spectrin-associated protein 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1313 - 326 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
     thymus    
    Respiratorylung   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion plasma
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES globular
    STRUCTURE
    motifs/domains
  • a leader peptide, a short N-terminal segment
  • a collagen-like region
  • a C-terminal fibrinogen-like domain
  • conjugated GlycoP
    mono polymer homomer , polymer
    HOMOLOGY
    interspecies ortholog to murine Fcna
    homolog to Drosophila CG5550
    intraspecies homolog to FCN2
    Homologene
    FAMILY
  • ficolin lectin family
  • CATEGORY immunity/defense , signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    text localized in secretory granules in the cytoplasm of neutrophils, monocytes, and type II alveolar epithelial cells in lung
    basic FUNCTION
  • functioning as a plasma protein with elastin-binding activity
  • involved in serum exerting lectin activity
  • like its family members, functions as a recognition molecule of the lectin complement pathway and plays an important role in innate immunity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text antimicrobial tumoral response (sensu invertebrata)
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with MASP1 and MASP2
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • binding to TGFB1 and elastin
  • CRP binding is enhanced by conformational bending at the neck region of FCN1, to avoid steric hindrance by the COL domain (Tanio 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS