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FLASH GENE
Symbol FCMR contributors: mct - updated : 26-05-2015
HGNC name Fc fragment of IgM receptor
HGNC id 14315
Location 1q32.1      Physical location : -
Synonym name
  • Fas apoptotic inhibitory molecule 3
  • IgM Fc receptor
  • immunoglobulin mu Fc receptor
  • FcR specific for pentameric IgM
  • regulator of Fas-induced apoptosis Toso
  • Synonym symbol(s) TOSO, FAIM3, FCmicroR
    DNA
    TYPE functioning gene
    STRUCTURE 18.75 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2773 - 278 - 2010 20042454
    8 - 3109 - 390 - 2010 20042454
    7 - 2835 - 306 - 2010 20042454
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  lowly
    Lymphoid/Immunelymph node   highly
     spleen   moderately
     thymus   moderately
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticgranulocyte Homo sapiens
    Blood/Hematopoieticmonocyte Homo sapiens
    Lymphoid/ImmuneB cell Homo sapiens
    Lymphoid/ImmuneT cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • immunoglobulin domain
  • an extracellular region with homology to the Ig variable (IgV) domains
  • a cytoplasmic region with partial homology to Fas-activated serine/threonine kinase (FAST kinase)
  • HOMOLOGY
    interspecies ortholog to murine Faim3
    Homologene
    FAMILY
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    basic FUNCTION
  • through internalization of IgM bound immune complexes, may play a role in immune surveillance and contribute to B cell activation
  • is a functional IgM receptor that is capable of activating signaling molecules, is regulated by IL2, and is not inherently an antiapoptotic molecule
  • is required for B cell differentiation and homeostasis, the prevention of autoreactive B cells, and responsiveness to antigenic challenge
  • critical regulatory function in innate immune activation
  • unique regulator of innate immune responses during bacterial infection and septic shock
  • plays a key role in the coordination of granulocyte phagocytosis, ROS production, and degranulation
  • unique regulator of inflammatory autoimmune responses
  • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS immunity/defense
    text
  • cellular defense response
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a receptor for IgM and may serve as an uptake receptor for IgM-opsonized antigens by B cells
  • regulates the balance between apoptotic and nonapoptotic death receptor signaling by facilitating RIPK1 ubiquitination
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in chronic lymphocytic leukemia patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinflammatory 
    attractive target for therapeutic intervention in multiple sclerosis
    ANIMAL & CELL MODELS
  • Fcmr-deficient mice have reduced numbers of developing B cells, splenic follicular and peritoneal B-2 cells, but increased levels of peritoneal B-1a cells and autoantibodies
  • Toso(-/-) mice do not develop severe experimental autoimmune encephalomyelitis (EAE), a mouse model for the human disease multiple sclerosis