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FLASH GENE
Symbol FCHO2 contributors: mct - updated : 26-08-2015
HGNC name FCH domain only 2
HGNC id 25180
Location 5q13.2      Physical location : 72.251.807 - 72.386.348
DNA
TYPE functioning gene
STRUCTURE 134.54 kb     26 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
25 - 4895 - 777 - 2004 15254787
26 - 4994 - 810 - 2004 15254787
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx    
Endocrineadrenal gland    
 pancreas    
Reproductivefemale systemplacenta   
Respiratoryrespiratory tracttrachea   
Urinarybladder    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal FCH domain
  • lacks the MP domain but has another lipid-binding domain, the EFC/F-BAR domain , and EFC domain bound to phosphatidylserine and phosphoinositides and deformed the plasma membrane and liposomes into narrow tubes
  • an evolutionarily conserved C-terminal FCHO homology (FOH) domain
  • a mu-homology domain (MHD) that binds directly to DPF sequences in DAB2 that also bind AP2
  • a 90 AA motif, found in both FCHO1, FCHO2 and SGIP proteins, that directly binds TFAP2A
  • HOMOLOGY
    interspecies homolog to murine Fcho2 (94.9pc)
    intraspecies homolog to SGIP1
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    text localized to clathrin-coated pits at the plasma membrane
    basic FUNCTION
  • FCHO1/FCHO2 sculpt the initial bud site and recruit the clathrin machinery for clathrin-coated vesicle (CCV) formation
  • regulates clathrin-mediated endocytosis through its interactions with membranes and EPS15
  • modulation in the expression level of FCHO1 and FCHO2, which have been reported to initiate clathrin-coated pits (CCPs), affects only the number of nucleations
  • regulates the size of clathrin structures, and its interaction with DAB2 is needed for LDLR endocytosis under conditions of low TFAP2A
  • organizes clathrin-coated structures and interacts with DAB2 for low-density lipoprotein receptor endocytosis
  • FCHO1 and FCHO2 are early-arriving proteins at surface clathrin assemblies and are speculated to act as compulsory coat nucleators, preceding the core clathrin adaptor TFAP2A
  • FCHO1, FCHO2 and SGIP1 stabilize nascent endocytic pits by exposing membrane and cargo binding sites on TFAP2A
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bound to EPS15, an important adaptor protein in clathrin-mediated endocytosis
  • FCHO2 is a major DAB2-interacting protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS