basic FUNCTION
| playing a role in promoting maturation and morphological differentiation of cerebellar neurons |
|
modulation in the expression level of FCHO1 and FCHO2, which have been reported to initiate clathrin-coated pits (CCPs), affects only the number of nucleations |
|
FCHO1 and FCHO2 are early-arriving proteins at surface clathrin assemblies and are speculated to act as compulsory coat nucleators, preceding the core clathrin adaptor TFAP2A |
|
FCHO1, FCHO2 and SGIP1 stabilize nascent endocytic pits by exposing membrane and cargo binding sites on TFAP2A |