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FLASH GENE
Symbol FCGR2B contributors: mct - updated : 13-02-2013
HGNC name Fc fragment of IgG, low affinity IIb, receptor for (CD32)
HGNC id 3618
Location 1q23      Physical location : 161.632.904 - 161.648.442
Synonym name
  • IgG Fc receptor II-b
  • low affinity immunoglobulin gamma Fc region receptor II-b
  • CD32 antigen
  • Synonym symbol(s) FCG2, FCG2B, FCR2, CD32, IGFR2, CD32B, CDw32
    DNA
    TYPE functioning gene
    STRUCTURE 15.01 kb     8 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence alternative promoter
    Binding site
    text structure
  • binding sites for ZNF140 and ZNF91 (to repression of FCGR2B transcription)
  • interaction of c-Jun with the FCGR2B promoter and c-Jun could act as transcriptional regulator of the FCGR2B promoter activity at this site
  • MAPPING cloned Y linked Y status confirmed
    Physical map
    PPOX 1q22 protoporphyrinogen oxidase B4GALT3 1q21-q23 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 ADAMTS4 1q23 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4 NDUFS2 1q23 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) FCER1G 1q23 Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide APOA2 1q21-q23 apolipoprotein A-II FLJ12770 1q23.1 hypothetical protein FLJ12770 NR1I3 1q23.1 nuclear receptor subfamily 1, group I, member 3 MPZ 1q22 myelin protein zero (Charcot-Marie-Tooth neuropathy 1B) SDHC 1q21 succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa LOC257177 1q23.1 similar to hypothetical protein MGC20470 LOC148430 1q23.1 similar to ribosomal protein S2; 40S ribosomal protein S2 LOC388709 1 LOC388709 LOC388710 1 LOC388710 FCGR2A 1q23 Fc fragment of IgG, low affinity IIa, receptor for (CD32) HSPA6 1q heat shock 70kDa protein 6 (HSP70B') FCGR3A 1q23 Fc fragment of IgG, low affinity IIIa, receptor for (CD16) FCGR3B 1q23 Fc fragment of IgG, low affinity IIIb, receptor for (CD16) FCGR2B 1q23 Fc fragment of IgG, low affinity IIb, receptor for (CD32) FREB 1q23.1 Fc fragment of IgG, low affinity IIb, receptor for (CD32) FLJ31052 1q23.1 hypothetical protein FLJ31052 DUSP12 1q22 dual specificity phosphatase 12 ATF6 1q22-q23 activating transcription factor 6 DKFZP586L151 1q23.1 DKFZP586L151 protein CAPON 1q23.1-q23.2 C-terminal PDZ domain ligand of neuronal nitric oxide synthase
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2114 - 290 - Magnusson (2004)
    7 - 2117 - 291 - Magnusson (2004)
    8 - 2171 - 309 - Magnusson (2004)
    8 - 2174 - 310 - Magnusson (2004)
    - - 2153 - 303 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
    Nervousbraindiencephalonamygdala  
    Reproductivefemale systemplacenta  highly
    Respiratorylung    
    Urinarykidney    
    Visualeyeuveachoroid  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Epithelialbarrier/liningretinal pigment epithelium (RPE)  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell Homo sapiensAdult
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • single chain transmembrane (TM) protein containing two Ig extracellular domains
  • a cytoplasmic tail with immunoreceptor tyrosine based inhibitory motifs (ITIM)
  • HOMOLOGY
    interspecies homolog to murine Fcgr2b
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • CATEGORY immunity/defense , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type 1 membrane protein
    basic FUNCTION
  • maintaining gamma immune system homeostasis through negative regulation of immune responses
  • involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B- cells
  • negative regulator of antibody production and inflammatory responses
  • may be having a prominent role in dendritic cell activity in response to interaction with particulate autoantigens (McGaha 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CD72 to modify susceptibility to systemic lupus erythematosus
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    translocation in malignant lymphoma
    constitutional     --low  
    in memory B cells from SLE patients, reflecting inadequate inhibitory signaling in SLE memory B cells
    Susceptibility
  • to systemic lupus erythematosus (SLE)
  • to malaria
  • Variant & Polymorphism SNP
  • I232T increased in SLE patients (decreasing affinity to lipid rafts and attenuating inhibitory effects on B cell receptor signaling)
  • homozygous -343 C/C genotype in the promoter is more frequent in SLE patients
  • 343G/C promoter polymorphism associated with SLE
  • a SNP abrogates receptor function and is strongly associated with susceptibility to SLE, but also associated with substantial protection against severe malaria (Willcocks 2010)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS