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FLASH GENE
Symbol FCER2 contributors: mct - updated : 13-05-2011
HGNC name Fc fragment of IgE, low affinity II, receptor for (CD23A)
HGNC id 3612
Location 19p13.3      Physical location : 7.753.642 - 7.767.032
Synonym name
  • cell differentiation antigen CD23 (p45), 50-45kDa, low affinity Fc epsilon RII-IgE receptor, identified by monoclonal antibodies BLAST-2, MHM6
  • C-type lectin domain family 4, member J
  • CD23 antigen
  • Synonym symbol(s) CD23, FCE2, CD23A, CLEC4J, IGEBF
    DNA
    TYPE functioning gene
    STRUCTURE 13.40 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 1620 37 321 - 2002 12022472
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node    
     spleen    
     thymus    
     tonsils    
    Respiratoryrespiratory tractlarynx   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticeosinophil Homo sapiens
    Blood/Hematopoieticmonocyte Homo sapiens
    Lymphoid/Immunedendritic cell Homo sapiens
    Lymphoid/Immunemacrophage Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a lectin "head," N-terminal "stalk," and C-terminal "tail" in the extracellular sequence
  • a leucine zipper
  • a transmembrane domain
  • a short cytoplasmic tail
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY immunity/defense , antigen
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • having essential roles in the regulation of Ige production and in the differentiation of B-cells (it is a B-cell-specific antigen)
  • low affinity receptor for IgE and in B cells has been proposed to play a role in the regulation of IgE synthesis
  • FCER2-mediated signal transduction pathways in human B cells and human monocytes are different
  • low-affinity receptor for immunoglobulin (Ig)E and plays important roles in the regulation of IgE responses (
  • FCER2-bound IgE augments and dominates recall responses through naive B cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other cleaved by a disintegrin and metalloproteinase 10 (ADAM10) and this cleavage influences the ability of FCER2 to regulate IgE
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in follicular lymphoma of the inguinal region
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    allergyasthm 
    could be targets for therapeutic intervention in allergic disease
    ANIMAL & CELL MODELS