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FLASH GENE
Symbol FCER1G contributors: mct - updated : 12 -11-201
HGNC name Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
HGNC id 3611
Location 1q23.3      Physical location : 161.185.086 - 161.189.038
Synonym symbol(s) FCE1G, FCRG
DNA
TYPE functioning gene
STRUCTURE 3.95 kb     5 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site   transcription factor
text structure
  • additional expression of Elf-1 in combination with Sp1 and GABP reduced FCER1G promoter activity
  • MAPPING cloned Y linked N status confirmed
    Physical map
    CD244 1q23.1 CD244 natural killer cell receptor 2B4 ITLN1 1q21.3 intelectin 1 (galactofuranose binding) LOC284679 1q23.1 similar to spermine synthase; spermidine aminopropyltransferase ITLN2 1q22-q23.5 intelectin 2 F11R 1q21.2-q21.3 F11 receptor USF1 1q22-q23 upstream transcription factor 1 LOC388708 1 similar to KAT protein LOC257106 1q23.1 hypothetical protein LOC257106 LNIR MGC33338 1q23.1 hypothetical protein MGC33338 PFDN2 1q23.1 prefoldin 2 NIT1 1q21-q22 nitrilase 1 DEDD 1q21.3 death effector domain containing HSPC155 1q23.1 hypothetical protein HSPC155 USP21 1q22 ubiquitin specific protease 21 PPOX 1q22 protoporphyrinogen oxidase B4GALT3 1q21-q23 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 ADAMTS4 1q23 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4 NDUFS2 1q23 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) FCER1G 1q23 Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide APOA2 1q21-q23 apolipoprotein A-II FLJ12770 1q23.1 hypothetical protein FLJ12770 NR1I3 1q23.1 nuclear receptor subfamily 1, group I, member 3 MPZ 1q22 myelin protein zero (Charcot-Marie-Tooth neuropathy 1B) SDHC 1q21 succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa LOC257177 1q23.1 similar to hypothetical protein MGC20470 LOC148430 1q23.1 similar to ribosomal protein S2; 40S ribosomal protein S2 LOC388709 1 LOC388709 LOC388710 1 LOC388710 FCGR2A 1q23 Fc fragment of IgG, low affinity IIa, receptor for (CD32) HSPA6 1q heat shock 70kDa protein 6 (HSP70B') FCGR3A 1q23 Fc fragment of IgG, low affinity IIIa, receptor for (CD16) FCGR3B 1q23 Fc fragment of IgG, low affinity IIIb, receptor for (CD16)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 591 - 86 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   highly
     pancreas   highly
     thyroid   highly
    Respiratorylung   moderately
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
     mast cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a short extracellular domain
  • a cytoplasmic tail with the immunoreceptor tyrosine based activation motif (ITAM)
  • mono polymer homomer , heteromer , dimer , tetramer
    HOMOLOGY
    interspecies ortholog to murine Fcer1g
    homolog to rattus Rn.9277
    homolog to C.elegans C16C4.1
    Homologene
    FAMILY CD3Z/FCER1G family
    CATEGORY receptor membrane tyrosine kinase
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I transmembrane protein
    basic FUNCTION
  • involved in allergic reactions
  • playing a critical role in allowing the ig E Fc receptor to reach the cell surface
  • may play the pivotal role in endothelial dysfunction through oxidative stress induced by hypercholesterolaemia
  • ITAM molecules, FCER1G, TREM2 and TYROBP play an important role in osteoclast development and activity
  • CD247 and FCER1G are integral membrane proteins that have subsequently been found to be obligate signaling adaptors for many immunoreceptors in different cell types
  • association of the adaptor modules FCER1G or CD247 with FCGR3A not only is required for progression of this receptor through the secretory pathway and cell surface expression but also protects the FCGR3A protein from degradation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • tetramer composed of an alpha, a beta and two disulfide-linked gamma chains
  • CLEC4E and CLEC4D form a disulfide-linked heterodimer associated with the FCER1G chain
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associates with various cell surface receptors to mediate intracellular signals
  • CRP generates suppressive macrophages through FCER1G
  • CD300C signaling is partially mediated by a direct association with the immune receptor tyrosine-based activation motif-bearing adaptor FCER1G
  • CD300LD recruited FCER1G as efficiently as CD300C
  • OSCAR and TREM2 are essential receptors that pair with adaptor molecules Fc receptor common gamma chain (FCR1G) and TYROBP respectively to induce calcium signalling
  • specific engagement of CD300C led to FCER1G-dependent activation of mast cells and monocytes
  • expression of the FCGR3A depends on a noncovalent association with the signaling dimers FCER1G and/or CD247
  • FCGR3A requires association with adaptor modules for cell surface expression but shows no preference for assembly with either CD247 or FCER1G
  • OSCAR and TREM2 are essential receptors that pair with adaptor molecules Fc receptor common gamma chain (FCR1G) and DAP12 respectively to induce calcium signalling
  • RRAS2 is essential for CD36-FCER1G-mediated platelet activation and for thrombus stability via control of RAP1B and integrins
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyneurodegenerative 
    restoration of FCER1G/Fyn signaling represents a new approach for the treatment of demyelinating diseases
    ANIMAL & CELL MODELS
  • murine FcRg deletion resulted in significantly decreased peripheral T cell apoptosis