protein
| TBC1D3 recruits F-box 8 (FBXW8), the substrate recognition domain of CUL7 E3 ligase |
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CRTC2 negatively feeds back to IRS1 via control of FBXW8 stability and localization |
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CRTC2 functions in the regulation of FBXW8 that allows FBXW8 to mediate IRS1 turnover following insulin stimulation |
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CUL7/FBXW8 ubiquitin ligase-mediated MAP4K1 degradation revealed a direct link and novel role of CUL7/FBXW8 ubiquitin ligase in the MAPK pathway, which plays a critical role in cell proliferation and differentiation |
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degradation of wildtype and mutant ATXN2 is dependent on FBXW8, and ATXN2 accumulation selectively modulates FBXW8 levels, while PARK2 might act indirectly through FBXW8 |
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MRFAP1 is an interactor of the F-box protein FBXW8, and is degraded by means of the ubiquitin ligase CUL7/FBXW8 during mitotic anaphase-telophase transition and accumulated in mitotic metaphase |
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CUL7/FBXW8-mediated destruction of MRFAP1 is a regulatory component monitoring the anaphase-telophase transition and preventing genomic instability |