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FLASH GENE
Symbol FBXW5 contributors: mct/npt/pgu - updated : 13-12-2016
HGNC name F-box and WD repeat domain containing 5
HGNC id 13613
Location 9q34.3      Physical location : 139.834.887 - 139.839.173
Synonym name
  • F-box and WD-40 domain protein 5
  • WD repeat-containing F-box protein FBW5
    • Synonym symbol(s) DKFZP434B205, MGC20962, Fbw5, RP11-229P13.10
    DNA
    TYPE anonymous DNA segment
    STRUCTURE 4.29 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text three alternatively spliced variants
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 splicing 2387 63 566 - 1999 10531037
    the longest isoform
    - splicing 2456 - 261 - 1999 10531037
  • contains an additional segment in the coding region resulting in a frameshift and an earlier translation termination (compared to variant 1)
  • isoform 2 is shorter and has a distinct C-terminus
    • - splicing 2379 - 213 - 1999 10531037
  • contains an additional segment (resulting in a frameshift and an earlier translation termination) and also lacks a downstream segment in the coding region (compared to variant 1)
  • isoform 3 is shorter and has a distinct C-terminus
    		•
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
    Reproductivefemale systemovary   
     female systemuteruscervix  
     male systemtestis   
    Skin/Tegumentskin    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminally located F-box motif (F-box motif functions to bridge a substrate protein to the CUL1
    • ROC1 E3 ligase via the SKP1 linker)
  • seven WD40 repeats occupying most of the rest of the sequence
    • mono polymer complex
    HOMOLOGY
    interspecies homolog to murine Fbxw5
    Homologene
    FAMILY
  • F-box protein family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • localized to both nucleus and cytosol
    • basic FUNCTION
  • probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation
  • negatively regulates MAP3K7 in the IL1B signaling pathway
  • cell-cycle-regulated protein with expression levels peaking at the G1/S transition
  • FBXW5 is a substrate of both PLK4 and APC/C, two established regulators of centriole duplication
  • enhances sumoylation of MYB in the nucleus, which suppresses MYB activity
  • FBXW5 may adopt a different protein conformation when interacting with TSC2 or MYB, which may selectively induce binding to ubiquitin or SUMO ligase components
    • CELLULAR PROCESS protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of a SCF protein ligase complex
  • component of the IL-1B-induced MAP3K7 complex
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with SKP1A
  • binds to TSC2 (TSC2 is recruited by FBXW5 to the DDB1/CUL4/ROC1 E3 ubiquitin ligase)
  • also binds to TSC1
  • binds SASS6 and promotes its ubiquitylation
  • substrate of both PLK4 and CDC20, two established regulators of centriole duplication
  • FBXW5 control the degradation of the centriole assembly factor SASS6
  • FBXW5 enhanced sumoylation of nuclear MYB and induced the localization of MYB to nuclear dot-like domains
  • FBXW5-driven fluctuation of EPS8 levels is an important mechanism that contributes to cell-shape changes during entry into-and exit from-mitosis
  • is a TSC2 binding receptor within CUL4 E3 ligase complex, and it promotes proteasomal degradation of TSC2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS