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FLASH GENE
Symbol FBXW2 contributors: npt/ - updated : 23-04-2008
HGNC name F-box and WD repeat domain containing 2
HGNC id 13608
Location 9q34      Physical location : 123.519.253 - 123.555.740
Synonym name
  • F-box and WD-40 domain protein 2
  • protein MD6
  • Synonym symbol(s) FBW2, Md6, Fwd2, MGC117371
    DNA
    TYPE functioning gene
    STRUCTURE 36.48 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    DBC1 9q32-q33 deleted in bladder cancer 1 CDK5RAP2 9q33.3 CDK5 regulatory subunit associated protein 2 LOC389788 9 similar to EGFL5 LOC392387 9 similar to Ahcy protein FBXW2 9q34 F-box and WD-40 domain protein 2 PSMD5 9q33.3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 PHF19 9q34.11 PHD finger protein 19 TRAF1 9q33-q34 TNF receptor-associated factor 1 C5 9q33 complement component 5 CEP1 9q33 centrosomal protein 1 RAB14 9q32-q34.11 RAB14, member RAS oncogene family LOC392388 9 similar to vacuolar H+-ATPase B subunit GSN 9q33.3 gelsolin (amyloidosis, Finnish type) MOST2 9q34.11 MOST2 protein STOM 9q34.1 stomatin a1/3GTP 9q34.11 alpha-1,3-galactosyltransferase pseudogene DAB2IP 9q33.1-q33.3 DAB2 interacting protein LOC158135 9q34.11 similar to H23L24.3.p NDUFA8 9q32.4-q34.41 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa FLJ46909 9q34.11 FLJ46909 protein LHX6 9q34.11 LIM homeobox 6 MGC2734 MRRF 9q33-q34.1 mitochondrial ribosome recycling factor PTGS1 9q32-q33.3 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) LOC347168 9q34.11 similar to Olfactory receptor 1J1 OR1J5 9q34.11 olfactory receptor, family 1, subfamily J, member 5
    regionally located site of loss in ovarian and bladder cancer
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 9186 51.4 454 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, checkpoint, G1S
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 40AA F-box motif near the N terminus
  • several WD40 repeats
  • HOMOLOGY
    Homologene
    FAMILY
  • F-box protein family
  • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • substrate recognition subunit of SCF ubiquitin protein ligase complex
  • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • one of the four subunits of the E3 ubiquitin protein ligase complex :(SCF) with SKP1, CUL1, RBX1, F-box protein bringing ubiquitin conjugating enzymesto substrates recruited by F-box
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • various target proteins
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS