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FLASH GENE
Symbol FBXO9 contributors: npt - updated : 13-01-2010
HGNC name F-box protein 9
HGNC id 13588
Location 6p12.1      Physical location : 52.929.795 - 52.965.668
Synonym name
  • F-box only protein 9
  • cross-immune reaction antigen
  • renal carcinoma antigen NY-REN-57
  • F-box protein Fbx9
  • Synonym symbol(s) FBX9, DKFZp434C0118, KIAA0936, NY-REN-57, VCIA1, dJ341E18.2
    DNA
    TYPE functioning gene
    STRUCTURE 35.88 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 4438 52.3 447 - Jin (2004)
    unique N terminal
    13 - 4688 51.1 437 - Jin (2004)
    additional exon at the 5' end
    13 - 4565 - 403 - Jin (2004)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 40AA F-box motif
  • HOMOLOGY
    Homologene
    FAMILY
  • F-box protein family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • phosphorylating dependent ubiquination
  • mitotic regulator, inhibiting the anaphase promoting complex (cyclosome APC) and preventing mitotic exit in cytostatic factor (CSF) arrested eggs
  • CELLULAR PROCESS cell cycle, division, mitosis
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • putative component of a E3 ubiquitin protein ligase complex (SCF) with SKP1, CUL1, RBX1 bringing ubiquitin conjugating enzymes to substrates recruited by F-box
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS