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FLASH GENE
Symbol FBXO8 contributors: npt/ - updated : 02-02-2008
HGNC name F-box protein 8
HGNC id 13587
Location 4q34.1      Physical location : 175.157.811 - 175.205.402
Synonym name
  • F-box only protein 8
  • F-box/SEC7 protein FBS
  • Synonym symbol(s) FBX8, FBS, DC10
    DNA
    TYPE functioning gene
    STRUCTURE 47.59 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC132604 4q34.1 GalNAc transferase 10 isoform-like GALNT7 4q31.1 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7) HMGB2 4q31 high-mobility group box 2 SAP30 4q34.1 sin3-associated polypeptide, 30kDa SCRG1 4q31-q32 sin3-associated polypeptide, 30kDa LOC391716 4 similar to 60S ribosomal protein L5 LOC389242 4 LOC389242 HAND2 4q33 heart and neural crest derivatives expressed 2 FLJ11539 4q34.1 hypothetical protein FLJ11539 MORF4 4q33-q34.1 mortality factor 4 LOC391717 4 similar to RAN protein LOC389243 4 LOC389243 FBXO8 4q34.1 F-box only protein 8 KIAA1712 4q34 KIAA1712 HPGD 4q34-q35 hydroxyprostaglandin dehydrogenase 15-(NAD) GLRA3 4q33-q34 glycine receptor, alpha 3 ADAM29 4q34 a disintegrin and metalloproteinase domain 29 LOC391718 4 similar to hypothetical protein MGC2776 GPM6A 4q34 glycoprotein M6A WDR17 4q34 WD repeat domain 17 TSARG2 4q34.2 testis and spermatogenesis cell related protein 2 ASB5 4q34.1 ankyrin repeat and SOCS box-containing 5 FLJ22649 4q34.2 hypothetical protein FLJ22649 similar to signal peptidase SPC22/23 VEGFC 4q34 vascular endothelial growth factor C FLJ10858 4q34.3 DNA glycosylase hFPG2 AGA 4q33-q35 aspartylglucosaminidase
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2564 37 319 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text highly in placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 40AA N terminal F-box motif
  • a C terminal very similar to a segment of yeast Sec7p
  • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae Sec7p (critical regulator of)
    Homologene
    FAMILY
  • F-box protein family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • phosphorylating dependent ubiquination
  • mitotic regulator, inhibiting the anaphase promoting complex (cyclosome APC) and preventing mitotic exit in cytostatic factor (CSF) arrested eggs
  • putatively promoting guanine-nucleotide exchange for ADP-ribosylation
  • CELLULAR PROCESS cell cycle, division, mitosis
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • putative component of a E3 ubiquitin protein ligase complex (SCF) with SKP1, CUL1, RBX1 bringing ubiquitin conjugating enzymes to substrates recruited by F-box
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS