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FLASH GENE
Symbol FBXO5 contributors: mct/npt - updated : 15-09-2009
HGNC name F-box protein 5
HGNC id 13584
Location 6q25.2      Physical location : 153.291.659 - 153.304.740
Synonym name
  • early mitotic inhibitor 1
  • F-box only protein 5
  • F-box protein Fbx5
  • Synonym symbol(s) FBX5, EMI1, Fbxo31
    DNA
    TYPE functioning gene
    STRUCTURE 13.08 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    regionally located site of loss in ovarian, breast, gastric cancers
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2269 - 401 - Reimann (2001)
    5 - 2109 - 447 - Reimann (2001)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   highly
    Lymphoid/Immunelymph node   predominantly
    Reproductivemale systemtestis  moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    cell cycle     cell cycle, checkpoint, M exit
    PROTEIN
    PHYSICAL PROPERTIES acid
    STRUCTURE
    motifs/domains
  • a F-box protein containing a zinc binding region (an approximately 40 amino acid motif)
  • HOMOLOGY
    interspecies ortholog to Xenopus early mitotic inhibitor-1
    ortholog to rattus Fbxo5 predicted
    ortholog to murine Fbxo5
    Homologene
    FAMILY
  • F-box protein family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • phosphorylating dependent ubiquination
  • mitotic regulator, inhibiting the anaphase promoting complex (cyclosome APC) and preventing mitotic exit in cytostatic factor (CSF) arrested eggs
  • arresting unfertilized eggs at metaphase of meiosis II
  • promoting cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC activator CDH1
  • acting as an ubiquitin protein ligase
  • promoting the ubiquitination and the degradation of some phosphorylated proteins
  • important APC/C inhibitor whose destruction may trigger activation of the APC/C at mitosis (Di Fiore 2007)
  • plays a crucial role in the cell cycle to couple DNA replication with mitosis (Di Fiore 2007)
  • its regulation plays a role in the G2 DNA damage checkpoint (Lee 2009)
  • CELLULAR PROCESS cell cycle,division,meiosis
    cell cycle, division, mitosis
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of a SCF (SKP1-cullin-F-box) protein ligase complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with PLK1 (PLK1 depletion induces DNA instability, which may be mediated by the accumulation of FBXO5, an inhibitor of APC/C, and geminin, an inhibitor of pre-prereplicative complex formation (Yim 2009)
  • cell & other
    REGULATION
    inhibited by ubiquitylated and destroyed in mitosis
    repressed by CDKN1A (down-regulates FBXO5 in cells arrested in G2 by DNA damage) (Lee 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS