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FLASH GENE
Symbol FBXO43 contributors: mlc - updated : 20-10-2004
HGNC name F-box protein 43
HGNC id 28521
Location 8q22.2      Physical location : 101.145.587 - 101.158.099
Synonym name early mitotic inhibitor 2
Synonym symbol(s) Fbx43, EMI2
DNA
TYPE functioning gene
STRUCTURE 12.00 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 3211 78 708 - Shoji (2006)
- - 3255 - 674 - Shoji (2006)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Nervousnerve    
Reproductivemale systemtestis   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a F-box domain
  • a IBR-type zinc finger
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization
  • ANAPC1 inhibitor, implicated as a component of cytostatic factor (CSF) is requires by MOS to induce M phase arrest
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    ubiquitin conjugation, third step
    a component part of a SCF (SKP1-cullin-F-box) protein ligase complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • may interact with CDC20
  • interaction with the protein phosphatase PPP2R4 (promoted by Rsk phosphorylation )
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS