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FLASH GENE
Symbol FBXO4 contributors: mct - updated : 06-11-2007
HGNC name F-box only protein 4
HGNC id 13583
Location 5p12      Physical location : 41.925.355 - 41.941.663
Synonym symbol(s) FBX4, FLJ10187, PINX3
DNA
TYPE functioning gene
STRUCTURE 16.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC253254 5p13.2 hypothetical LOC253254 OSMR 5p13.2 oncostatin M receptor KIAA1999 MGC39830 5p13.2 hypothetical protein MGC39830 FYB 5p13.1 FYN binding protein (FYB-120/130) C9 5p13 complement component 9 DAB2 5p13-p12.1 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) LOC285634 5p13.2 similar to DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26; RNA helicase HDB; deleted in cancer 1; RNA helicase HDB/DICE1; DEAD box protein LOC389285 5 LOC389285 PTGER4 5p13.1 prostaglandin E receptor 4 (subtype EP4) OSRF 5p15.2-p12 osmosis responsive factor PRKAA1 5p14-p11 protein kinase, AMP-activated, alpha 1 catalytic subunit LOC389286 5 similar to FKSG62 RPL37 5p13-p12 ribosomal protein L37 CARD6 5p12 caspase recruitment domain family, member 6 C7 5p13 complement component 7 FLJ40243 5p13.1 hypothetical protein FLJ40243 C6 5p13 complement component 6 LOC345557 5p13.1 similar to RIKEN cDNA B130016O10 gene TCP1L2 5pter-p15.32 t-complex 1-like 2 OXCT 5p13 3-oxoacid CoA transferase LOC285636 5p13.1 hypothetical protein LOC285636 FBXO4 5p12 F-box only protein 4 LOC391779 5 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) GHR 5p13.1-p12 growth hormone receptor LOC389287 5 similar to synaptonemal complex protein SYP-1, SYnaPsis in meiosis abnormal SYP-1 (56.6 kD) (syp-1) SEPP1 5q31 selenoprotein P, plasma, 1 LOC391780 5 similar to peptidyl-Pro cis trans isomerase LOC340065 5p13.1 hypothetical LOC340065 LOC389288 5 LOC389288 LOC389289 5 similar to annexin II receptor LOC153684 5p13.1 hypothetical protein LOC153684 FLJ90723 5p13.1 hypothetical protein FLJ90723 FLJ10246 5p13.1 hypothetical protein FLJ10246 MGC42105 5p13.1 hypothetical protein MGC42105 HMGCS1 5p14-p13 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) CCL28 5p12 chemokine (C-C motif) ligand 28 FLJ21657 5p12 hypothetical protein FLJ21657 FLJ32363 5p12 FLJ32363 protein PAIP1 5q31.1-q31.3 Homo sapiens polyadenylate binding protein-interacting protein 1 (PAIP1), transcript variant 3, mRNA. NNT 5p13.1-cen nicotinamide nucleotide transhydrogenase FGF10 5p13-p12 fibroblast growth factor 10 MRPS30 5q11 mitochondrial ribosomal protein S30
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1523 44.1 387 - Cenciarelli, Ewing (2007)
divergent in the 3' end
- - 1746 34.9 307 - Cenciarelli, Ewing (2007)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach   highly
Respiratoryrespiratory tractlarynx  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a 40AA F-box motif
HOMOLOGY
Homologene
FAMILY F-box protein family, Fbxs class
CATEGORY adaptor , regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • phosphorylating dependent ubiquination
  • mitotic regulator, inhibiting the anaphase promoting complex (cyclosome APC) and preventing mitotic exit in cytostatic factor (CSF) arrested eggs
  • may play a critical role in telomere maintenance (central regulator of TERF1 protein abundance)
  • like RLIM, is a critical negative regulator of TERF1 protein abundance and represents a new pathway for telomere maintenance by regulating the level of TERF1 at telomeres (Her 2009)
  • CELLULAR PROCESS cell cycle, division, mitosis
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component putative component of a E3 ubiquitin protein ligase complex (SCF) with SKP1, CUL1, RBX1 bringing ubiquitin conjugating enzymes to substrates recruited by F-box
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with TERF1 and promotes its ubiquitination
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    reduces endogenous TERF1 protein levels and causes progressive telomere elongation in cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS