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FLASH GENE
Symbol FBXO30 contributors: mct - updated : 12-05-2020
HGNC name F-box protein 30
HGNC id 15600
Location 6q24.3      Physical location : 146.119.273 - 146.135.921
Synonym name
  • F-box only protein, helicase, 18
  • muscle ubiquitin ligase of the SCF complex in atrophy-1
  • Synonym symbol(s) MGC21674, Fbx30, FLJ41030, MUSA1
    DNA
    TYPE functioning gene
    STRUCTURE 70.91 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 9051 82.2 745 - 2004 15520277
    3 - 8962 - 745 - 2004 15520277
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    cell cycle     cell cycle, checkpoint, G1S
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 40AA F-box motif
  • HOMOLOGY
    Homologene
    FAMILY
  • F-box protein family
  • CATEGORY regulatory , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • phosphorylating dependent ubiquination
  • mitotic regulator, inhibiting the anaphase promoting complex (cyclosome APC) and preventing mitotic exit in cytostatic factor (CSF) arrested eggs
  • regulates chromosome segregation of oocyte meiosis
  • mediates RARG ubiquitination and regulates BMP signaling in neural tube defects
  • CELLULAR PROCESS cell cycle, division, mitosis
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • putative component of a E3 ubiquitin protein ligase complex (SCF) with SKP1, CUL1, RBX1 bringing ubiquitin conjugating enzymes to substrates recruited by F-box
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BMP-SMAD1/5/8 signaling negatively regulates a gene (FBXO30) that encodes a ubiquitin ligase required for muscle loss
  • FBXO30 specifically interacts with the bipolar spindle kinesin KIF11 and FBXO30-KIF11 interaction is a critical checkpoint in mammopoiesis with a critical role for ubiquitinylation-regulated KIF11 oscillation in the cell cycle
  • SLBP is a novel substrate of FBXO30 (overexpression caused by FBXO30 depletion results in a remarkable overload of histone H3 on chromosomes that excessively condenses chromosomes and inhibits chromosome segregation)
  • FBXO30 acts as an E3 ubiquitin ligase and targets RARG for ubiquitination and proteasomal degradation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in nasopharyngeal carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Fbxo30(-/-) mice exhibit normal development, growth, lifespan, and fertility, the females fail to nurture their offspring as a result of defective mammopoiesis