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FLASH GENE
Symbol FBXO3 contributors: mct - updated : 26-06-2015
HGNC name F-box protein 3
HGNC id 13582
Location 11p13      Physical location : 33.762.491 - 33.796.071
Synonym name
  • F-box only protein 3
  • F-box protein FBX3
    • Synonym symbol(s) FBX3, FBA, DKFZp564B092
    DNA
    TYPE functioning gene
    STRUCTURE 33.58 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2410 53.6 472 - 2000 10828603
    10 - 1654 46.6 41.6 415 2000 10828603
    truncated
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 40AA N terminal F-box motif
  • a highly acidic D/E rich domains
  • two poly R at the C terminmus (lacking in variant 2)
    • HOMOLOGY
    Homologene
    FAMILY
  • FBXO type protein family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • phosphorylating dependent ubiquination
  • mitotic regulator,inhibiting the anaphase promoting complex (cyclosome APC) and preventing mitotic exit in cytostatic factor (CSF) arrested eggs
  • potently stimulates cytokine secretion from human inflammatory cells by mediating the degradation of the TRAF inhibitory protein, FBXL2
  • plays an important role in controlling the stability of NEDD4
    • CELLULAR PROCESS cell cycle, division, mitosis
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • putative component of a E3 ubiquitin protein ligase complex (SCF) with SKP1, CUL1, RBX1 bringing ubiquitin conjugating enzymes to substrates recruited by F-box
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with and targets SMURF1 for poly-ubiquitination and proteasomal degradation
  • FBXO3 targets all the NEDD4 family members for their degradation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS