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FLASH GENE
Symbol FBXO28 contributors: SGE/npt - updated : 23-03-2010
HGNC name F-box protein 28
HGNC id 29046
Location 1q42.11      Physical location : 224.301.790 - 224.349.749
Synonym symbol(s) FLJ10766, KIAA0483, Fbx28
DNA
TYPE functioning gene
STRUCTURE 47.95 kb     5 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 5457 - 368 - Jin (2004)
  • isoform a
    • 4 - 5261 - 179 - Jin (2004)
  • isoform b
    		•
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus    
    Urinarybladder    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one F-box domain
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Fbxo28 (94.8pc)
    homolog to rattus Fbxo28 (95.1pc)
    Homologene
    FAMILY
  • cyclin-like F-box
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • probably recognizing and binding to some phosphorylated proteins nd promoting their ubiquitination and degradation (Jin 2004)
    • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of a SCF protein ligase complex
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SKP1 and their ubiquitination targets (Jin 2004)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS