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FLASH GENE
Symbol FBXO22 contributors: npt/ - updated : 23-09-2004
HGNC name F-box protein 22
HGNC id 13593
Location 15q24.1      Physical location : 76.196.199 - 76.226.942
Synonym name
  • FIST domain containing 1
  • F-box protein FBX22p44
  • F-box only protein 22
    • Synonym symbol(s) FBX22, FISTC1, FLJ13986, MGC31799
    DNA
    TYPE functioning gene
    STRUCTURE 30.74 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 276 30.9 1822 - Cencierelli
    distinct 3' sequence
    - - 403 45.1 2818 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 40AA F-box motif
    • HOMOLOGY
    Homologene
    FAMILY
  • F-box protein family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • phosphorylating dependent ubiquination
  • mitotic regulator,inhibiting the anaphase promoting complex (cyclosome APC) and preventing mitotic exit in cytostatic factor (CSF) arrested eggs
    • CELLULAR PROCESS cell cycle, division, mitosis
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • putative component of a E3 ubiquitin protein ligase complex (SCF) with SKP1, CUL1, RBX1 bringing ubiquitin conjugating enzymes to substrates recruited by F-box
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS