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FLASH GENE
Symbol FBXO21 contributors: npt/ - updated : 23-09-2004
HGNC name F-box only protein 21
HGNC id 13592
Location 12q24.21      Physical location : 117.581.585 - 117.628.300
Synonym name F-box protein 21
Synonym symbol(s) FBX21, KIAA0875, DKFZp434G058, FLJ90233, MGC26682
DNA
TYPE functioning gene
STRUCTURE 46.72 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
KIAA0682 12q23.3-q24.2 nucleoside diphosphate kinase B-like pseudogene TBX5 12q24.1 T-box 5 LOC387886 12 LOC387886 LOC390361 12 similar to microtubule-associated proteins 1A/1B light chain 3 LOC386654 12q24.1-q24.2 OSTF1 pseudogene TBX3 12q24.1 T-box 3 (ulnar mammary syndrome) LOC387887 12 LOC387887 KIAA1025 LOC387888 12 LOC387888 FLJ21415 12q24.22 hypothetical protein FLJ21415 FLJ14627 12q24.22-q24.23 hypothetical protein FLJ14627 HRK 12q24.23 harakiri, BCL2 interacting protein (contains only BH3 domain) FBXW8 12q24.21 F-box and WD-40 domain protein 8 TSC 12q24.23 hypothetical protein FLJ20607 FBXO21 12q24.21 F-box only protein 21 NOS1 12q24.2-q24.31 nitric oxide synthase 1 (neuronal) KSR2 12q24.23 kinase suppressor of Ras-2 RFC5 12q24.2-q24.3 replication factor C (activator 1) 5, 36.5kDa WSB2 12q24.23 WD repeat and SOCS box containing protein 2 FLJ20674 12q24.23 hypothetical protein FLJ20674 PBP 12q24.23 prostatic binding protein JIK 12q24.2 prostatic binding protein SDS3 12q24.23 likely ortholog of mouse Sds3 LOC144747 12q24.23 hypothetical protein LOC144747 H11 LOC387889 12 hypothetical gene supported by U41745; NM_014891 MGC39827 12q24.23 hypothetical protein MGC39827 LOC387890 12 similar to hypothetical protein C130069F04 PRKAB1 12q24.1-q24.3 protein kinase, AMP-activated, beta 1 non-catalytic subunit CIT 12q24.2 citron (rho-interacting, serine/threonine kinase 21) LOC92558 12q24.31 hypothetical protein LOC92558 RAB35 12q24.31 RAB35, member RAS oncogene family GCN1L1 12q24.3 GCN1 general control of amino-acid synthesis 1-like 1 (yeast) RPLP0 12q24.2 ribosomal protein, large, P0 PXN 12q24 paxillin FLJ23042 12q24.31 hypothetical protein FLJ23042 LOC283458 12q24.31 nucleoside diphosphate kinase B-like pseudogene
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 4200 70.3 628 - Cenciarelli
- - 4180 70 621 - Cenciarelli
lacking 7AA internal AAs
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 40AA F-box motif
  • a C terminus homologous to that of rat Nfb42
    • HOMOLOGY
    Homologene
    FAMILY
  • F-box protein family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • phosphorylating dependent ubiquination
  • mitotic regulator,inhibiting the anaphase promoting complex (cyclosome APC) and preventing mitotic exit in cytostatic factor (CSF) arrested eggs
    • CELLULAR PROCESS cell cycle, division, mitosis
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • putative component of a E3 ubiquitin protein ligase complex (SCF) with SKP1, CUL1, RBX1 bringing ubiquitin conjugating enzymes to substrates recruited by F-box
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS