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FLASH GENE
Symbol FBXO15 contributors: mct - updated : 08-01-2011
HGNC name F-box only protein 15
HGNC id 13617
Location 18q22.3      Physical location : 71.740.587 - 71.815.100
Synonym symbol(s) FBX15, MGC39671
DNA
TYPE functioning gene
STRUCTURE 74.62 kb     10 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 1767 - 434 - 2003 12665572
10 - - - - - 2003 12665572
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticprogenitor cell Homo sapiens
cell lineage progenitor of mesodermal lineage (MPCs)
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • probably a receptor for ubiquitination targets
  • inducing pluripotent stem (iPS) cells (hereafter called FBXO15 iPS cells) similar to embryonic stem (ES) cells in morphology, proliferation and teratoma formation, but different with regards to gene expression and DNA methylation patterns
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to autism
    Variant & Polymorphism other
  • region of hemizygosity including TCF4, NETO1, and FBXO15 significantly more likely to exhibit autistic-like behaviors
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS