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FLASH GENE
Symbol FBXO11 contributors: mct/npt/pgu - updated : 19-10-2016
HGNC name F-box protein 11
HGNC id 13590
Location 2p16.3      Physical location : 48.034.060 - 48.132.932
Synonym name
  • vitiligo-associated protein VIT-1
  • F-box only protein 11
  • ubiquitin protein ligase E3 component n-recognin 6
  • Synonym symbol(s) FBX11, VIT1, FLJ12673, MGC44383, PRMT9, UBR6, UG063H01
    DNA
    TYPE functioning gene
    STRUCTURE 99.47 kb     23 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    23 - 4070 - 927 - 2007 1709874
    18 - 2567 76.4 686 - 2007 1709874
    16 - 2154 65.43 585 - 2007 1709874
    23 - 3859 94 843 - 2007 1709874
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
     thyroid   highly
    Lymphoid/Immunelymph node   highly
    Nervousbrainforebraincerebral lobefrontal 
    Reproductivemale systemtestis   
    Respiratoryrespiratory tracttrachea  highly
    Skin/Tegumentskin   highly Homo sapiens
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Connective    
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
     fibroblast
    Skin/Tegumentkeratinocyte
    Skin/Tegumentmelanocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal 40 amino acid F-box motif common to all F-box protein family members
  • 19 PbH1 repeats
  • a large domain with homology to the bacterial periplasmic protein NosD, a component of the nitrous oxide reductase complex
  • a zinc finger-like domain called a UBR box at the C terminus, 70-AAs UBR box functioning as a common structural element essential for binding to all known destabilizing N-terminal residues
  • HOMOLOGY
    interspecies ortholog to murine Fbxo11
    ortholog to rattus fbxo11
    Homologene
    FAMILY
  • F-box protein family
  • PRMT family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    intracellular,nucleus,nucleolus
    text
  • BCL6 and FBXO11 co-localized in the nucleus where they showed overlapping, punctate staining throughout the nucleoplasm
  • basic FUNCTION
  • may be modulating MSH6 expression
  • may be recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation
  • ubiquitination and degradation
  • acting as a Nedd8 ligase for TP53
  • protein arginine methyltransferase, that symmetrically dimethylates arginine residues
  • plays an important role in regulating proliferation and apoptosis of melanocytes, and functional export of tyrosinase from ER in vitiligo melanocytes
  • haplo-insufficient tumour suppressor gene
  • promotes the degradation of DTL during an unperturbed cell cycle to promote efficient progression through S and G 2/M phases of the cell cycle
  • BTRC, FBXW7, FBXL14, FBXO45, FBXL5, FBXO11 play in controlling EMT during development and cancer progression, a process dependent on post-translational modifications that govern their interaction with target proteins
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the Skp1-Cullin1-F-box (SCF) complex
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacting with TP53 (inhibits p53 activity without affecting its stability, and promoting the neddylation of TP53)
  • directly controls the ubiquitin-mediated degradation of BCL6 and FBXO11-dependent degradation of BCL6 is ERK-independent
  • interacts with DTL, a DCAF protein that controls cell-cycle progression, and recruits DTL to the SCF(FBXO11) complex to promote its proteasomal degradation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in vitiligo melanocytes
    tumoral   deletion   loss of function
    in multiple diffuse large B-cell lymphoma (DLBCL)cell lines, and this inactivation of FBXO11 correlated with increased levels and stability of BCL6
    Susceptibility to vitiligo
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS