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FLASH GENE

Symbol

FBXL7

contributors: npt/ - updated : 21-09-2004

HGNC name	F-box and leucine-rich repeat protein 7
HGNC id	13604

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	5p14.1-p13.3      Physical location : 15.500.304 - 15.939.900
Synonym symbol(s)	FBL6, FBL7, KIAA0840

DNA

TYPE	functioning gene
STRUCTURE	439.60 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed FBXL7 4 - 4562 54.4 491 - -

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive liver         Respiratory lung         Urinary kidney

cell lineage

cell lines

fluid/secretion

at STAGE

cell cycle

cell cycle, checkpoint, G1S

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal serine-rich region
	40AA F-box motif l
	twelve leucine-rich repeats (LRR) cysteine-containing subfamily at C terminus

HOMOLOGY

Homologene

FAMILY

F-box protein family

CATEGORY

adaptor

SUBCELLULAR LOCALIZATION

intracellular

basic FUNCTION	phosphorylation dependent uniquination
	substrate recognition subunit of SCF ubiquitin protein ligase complex

CELLULAR PROCESS

protein, ubiquitin dependent proteolysis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

one of the four subunits of the E3 ubiquitin protein ligase complex :(SCF) with SKP1, CUL1, RBX1, F-box protein bringing ubiquitin conjugating enzymes to substrates recruited by F-box

INTERACTION

DNA

RNA

small molecule

protein

various target proteins

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS