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FLASH GENE
Symbol FBXL7 contributors: npt/ - updated : 21-09-2004
HGNC name F-box and leucine-rich repeat protein 7
HGNC id 13604
Location 5p14.1-p13.3      Physical location : 15.500.304 - 15.939.900
Synonym symbol(s) FBL6, FBL7, KIAA0840
DNA
TYPE functioning gene
STRUCTURE 439.60 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC285694 5p15.2 hypothetical LOC285694 LOC391738 5 similar to 60S ribosomal protein L29 (Cell surface heparin binding protein HIP) DNAH5 5p15-p14 dynein, axonemal, heavy polypeptide 5 TRIO 5p15.2 triple functional domain (PTPRF interacting) FLJ11127 5p15.2 hypothetical protein FLJ11127 LOC391739 5 similar to chaperonin containing TCP1, subunit 6A (zeta 1); chaperonin containing T-complex subunit 6 EEF1AL11 5p15.1 eukaryotic translation elongation factor 1 alpha-like 11 LOC90268 5p15.2 hypothetical protein BC007706 ANKH 5p15.2-p14.1 ankylosis, progressive homolog (mouse) LOC391740 5 similar to selenophosphate synthetase 2; selenide,water dikinase 2; selenium donor protein 2; selenophosphate synthase LOC391741 5 similar to actin, gamma, cytoplasmic FBXL7 5p14.1-p13.3 F-box and leucine-rich repeat protein 7 LOC345722 5p15.1 similar to KIAA1399 protein ZPR9 5p15.1 zinc finger-like protein 9 FLJ20152 5p15.1 hypothetical protein FLJ20152 LOC389275 5 LOC389275 MYO10 5p15-p14.3 myosin X FLJ34047 5p15.1 hypothetical protein FLJ34047 BASP1 5p15.1-p14 brain abundant, membrane attached signal protein 1 FTHL10 5p15.1 ferritin, heavy polypeptide-like 10 LOC285697 5p15.1 similar to Transcription initiation factor TFIID 28 kDa subunit (TAFII-28) (TAFII28) (TFIID subunit p30-beta) LOC340096 5p15.1 similar to histone (15.4 kD) (his-72)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 4562 54.4 491 - -
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver    
Respiratorylung    
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
cell cycle     cell cycle, checkpoint, G1S
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal serine-rich region
  • 40AA F-box motif l
  • twelve leucine-rich repeats (LRR) cysteine-containing subfamily at C terminus
  • HOMOLOGY
    Homologene
    FAMILY
  • F-box protein family
  • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • phosphorylation dependent uniquination
  • substrate recognition subunit of SCF ubiquitin protein ligase complex
  • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • one of the four subunits of the E3 ubiquitin protein ligase complex :(SCF) with SKP1, CUL1, RBX1, F-box protein bringing ubiquitin conjugating enzymes to substrates recruited by F-box
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • various target proteins
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS