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FLASH GENE
Symbol FBXL6 contributors: - updated : 21-09-2004
HGNC name F-box and leucine-rich repeat protein 6
HGNC id 13603
Location 8q24-q25      Physical location : 145.579.091 - 145.582.132
Synonym symbol(s) FBL6
DNA
TYPE functioning gene
STRUCTURE 3.00 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 9900 - 539 insertion 18nt Cinchiarelli
- - 17810 - 533 - Cinchiarelli
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • F-box 40AA motif
  • leucine-rich repeats at the C terminus
  • putative SCF ubiquitin ligase
  • HOMOLOGY
    Homologene
    FAMILY F-box protein family
    CATEGORY adaptor , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • phosphorylation dependent uniquination
  • substrate recognition subunit of SCF ubiquitin protein ligase complex
  • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • one of the four subunits of the E3 ubiquitin protein ligase complex (SCF) with SKP1, CUL1, RBX1, F box protein bringing ubiquitin conjugating enzymes to substrates recruited by F-box
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS