Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol FBXL6 contributors: - updated : 21-09-2004
HGNC name F-box and leucine-rich repeat protein 6
HGNC id 13603
Location 8q24-q25      Physical location : 145.579.091 - 145.582.132
Synonym symbol(s) FBL6
DNA
TYPE functioning gene
STRUCTURE 3.00 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
CYC1 8q24.3 cytochrome c-1 DKFZP434N1923 8q24.3 hypothetical protein DKFZp434N1923 MAF1 8q24.3 homolog of yeast MAF1 KIAA1875 8q24.3 hypothetical protein KIAA1875 LOC51236 8q24.3 brain protein 16 LOC392276 8 similar to RIKEN cDNA 1700091F14 LOC392277 8 similar to RIKEN cDNA 1700091F14 KIAA1833 8q24.3 hypothetical protein KIAA1833 BOP1 8q24.3 block of proliferation 1 HSF1 8q24.3 heat shock transcription factor 1 DGAT1 8q24.3 diacylglycerol O-acyltransferase homolog 1 (mouse) DKFZp547F072 8q24.3 hypothetical protein DKFZp547F072 SCRT1 8q24.3 scratch homolog 1, zinc finger protein (Drosophila) LOC340393 8q24.3 similar to unnmaed protein product FBXL6 8q24-q25 F-box and leucine-rich repeat protein 6 FLJ11856 8q24.3 putative G-protein coupled receptor GPCR41 ADCK5 8q24.3 aarF domain containing kinase 5 CPSF1 8q24-q23 cleavage and polyadenylation specific factor 1, 160kDa SLC39A4 8q24.3 solute carrier family 39 (zinc transporter), member 4 VPS28 8q24.3 vacuolar protein sorting 28 (yeast) NFKBIL2 8q24.3 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2 MGC13010 8q24.3 hypothetical protein MGC13010 KIFC2 8q24.3 likely ortholog of mouse kinesin family member C2 FOXH1 8q24.3 forkhead box H1 PPP1R16A 8q24.3 protein phosphatase 1, regulatory (inhibitor) subunit 16A GPT 8q24.3 glutamic-pyruvate transaminase (alanine aminotransferase) LOC113655 8q24.3 hypothetical protein BC011982 RECQL4 8q24.3 RecQ protein-like 4 KIAA0014 8q24.3 RecQ protein-like 4
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 9900 - 539 insertion 18nt Cinchiarelli
- - 17810 - 533 - Cinchiarelli
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • F-box 40AA motif
  • leucine-rich repeats at the C terminus
  • putative SCF ubiquitin ligase
  • HOMOLOGY
    Homologene
    FAMILY F-box protein family
    CATEGORY adaptor , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • phosphorylation dependent uniquination
  • substrate recognition subunit of SCF ubiquitin protein ligase complex
  • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • one of the four subunits of the E3 ubiquitin protein ligase complex (SCF) with SKP1, CUL1, RBX1, F box protein bringing ubiquitin conjugating enzymes to substrates recruited by F-box
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS