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FLASH GENE
Symbol FBXL3 contributors: mct - updated : 30-04-2015
HGNC name F-box and leucine-rich repeat protein 3
HGNC id 13599
Location 13q22.3      Physical location : 77.579.389 - 77.601.331
Synonym name F-box and leucine-rich repeat protein 3A
Synonym symbol(s) FBL3A, FBL3, FBXL3A
DNA
TYPE functioning gene
STRUCTURE 25.86 kb     5 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 3572 - 428 - 2000 10945468
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
cell cycle     cell cycle, checkpoint, G1S
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • putative nuclear localization signal (NLS) sequence KRPR
  • 40AA F-box motif
  • several WD40 repeats
  • leucine repeats (LRR) at the C terminus, and C-terminal LRR domain that attenuates the interaction of SKP1, suggesting that a yet unknown protein associated with the C-terminal domain of FBXL3 and inhibited SCF complex formation
  • HOMOLOGY
    Homologene
    FAMILY F-box protein family
    CATEGORY adaptor , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    text nuclear localization of FBXL3
    basic FUNCTION
  • phosphorylation dependent ubiquitination
  • substrate recognition subunit of SCF ubiquitin protein ligase complex
  • central role for FBXL3 in mammalian circadian timekeeping
  • combined actions of FBXL21 and FBXL3 play a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation
  • dual roles of FBXL3 in the circadian feedback loops are important for period determination and robustness of the clock
  • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component one of the four subunits of the E3 ubiquitin protein ligase complex:(SCF) with SKP1, CUL1, RBX1, F-box protein bringing ubiquitin conjugating enzymes to substrates recruited by F-box
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • various target proteins
  • FBXL21 stabilized CRY1 and CRY2 and antagonized the destabilizing action by FBXL3
  • CRY1 is an endogenous substrate for FBXL21- and FBXL3-catalyzed ubiquitination
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    low expressed in small cell carcinoma lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS