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FLASH GENE
Symbol FBXL20 contributors: mlc - updated : 17-11-2007
HGNC name F-box and leucine-rich repeat protein 20
HGNC id 24679
Location 17q21.2      Physical location : 37.408.896 - 37.557.909
Synonym name
  • F-box/LRR-repeat protein 2-like
  • F-box protein FBL2
  • SCRAPPER
  • Synonym symbol(s) MGC15482, FBL20, FBL2, SCR, SCRAPPER
    DNA
    TYPE functioning gene
    STRUCTURE 141.00 kb     15 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 2423 - 436 - Yao (2007)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     mouthtongue  predominantly
    Lymphoid/Immunespleen    
    Reproductivefemale systembreastmammary gland predominantly
     female systemovary   
    Respiratoryrespiratory tractlarynx   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose   
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one N-terminal F box
  • 12 tandem leucine-rich repeats
  • a CAAX domain, a carboxyl-terminal membrane-sorting signal induced by prenylation
  • HOMOLOGY
    interspecies homolog to murine Fbxl20 (99.8pc)
    intraspecies homolog to 76.8 p 100 similar throughout to FBXL2
    Homologene
    FAMILY
    CATEGORY unknown/unspecified , antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text localized on presynaptic membrane
    basic FUNCTION
  • may be involved in ubiquitination
  • synapse-localized E3 ubiquitin ligase, which regulates neural transmission
  • having an essential function in regulating proteasome-mediated degradation of RIM1 required for synaptic tuning
  • plays a significant role in regulation of neurotransmitter release
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of SCF complex, formed by SKP1, cullin and F-box proteins
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SKP1A and CUL1
  • directly binds and ubiquitinates RIMS1, a modulator of presynaptic plasticity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS