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FLASH GENE
Symbol FBXL2 contributors: mct - updated : 27-03-2013
HGNC name F-box and leucine-rich repeat protein 2
HGNC id 13598
Location 3p24.3      Physical location : 33.318.933 - 33.428.756
Synonym name
  • F-box protein FBL2/FBL3
  • F-box protein containing leucine-rich repeats
  • Synonym symbol(s) FBL2, FBL3, DKFZP564P0622
    DNA
    TYPE functioning gene
    STRUCTURE 109.82 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC391524 3 similar to Thyroid hormone receptor-associated protein complex 150 kDa component (Trap150) SIMP 3p22.3 source of immunodominant MHC-associated peptides OSBPL10 3p22.3 oxysterol binding protein-like 10 LOC344787 3p22.3 similar to KIAA2033 protein KIAA0089 3p22.3 similar to KIAA2033 protein LOC391525 3 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) CKLFSF8 3p22.3 chemokine-like factor super family 8 CKLFSF7 3p22.3 chemokine-like factor super family 7 CKLFSF6 3p22.3 chemokine-like factor super family 6 LOC285260 3p22.3 similar to ribosomal protein L31 DNCLI1 3p22.2 dynein, cytoplasmic, light intermediate polypeptide 1 LOC391526 3 similar to Immunoglobulin-binding protein 1 (CD79a-binding protein 1) (B cell signal transduction molecule alpha 4) (Alpha 4 protein) CNOT10 3p22.3 CCR4-NOT transcription complex, subunit 10 LOC389101 3 similar to 60S ribosomal protein L23a LOC389102 3 similar to YPLR6490 LOC131405 3p22.3 similar to abnormal cell LINeage LIN-41, heterochronic gene; Drosophila dappled/ vertebrate TRipartite Motif protein related; B-box zinc finger, Filamin and NHL repeat containing protein (123.8 kD) (lin-41) CCR4 3p24 chemokine (C-C motif) receptor 4 LOC389103 3 LOC389103 GLB1 3p21.33 galactosidase, beta 1 CRTAP 3p22 cartilage associated protein KIAA0527 3p22.3 KIAA0527 protein FBXL2 3p24.3 F-box and leucine-rich repeat protein 2 UBP1 3p22.2 upstream binding protein 1 (LBP-1a) CLASP2 3p24.2-p21.33 cytoplasmic linker associated protein 2 LOC389104 3 similar to CLIP-associating protein 1; multiple asters 1 PDCD6IP 3p22.3 programmed cell death 6 interacting protein LOC285307 3p22.2 hypothetical LOC285307 FECHP 3p23-p22 ferrochelatase pseudogene
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 3000 - 423 - 2000 10945468
    14 - 2793 - 355 - 2000 10945468
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    endocrinebraindiencephalonpituitary  
    Endocrinepancreas    
    Nervousbrainforebraincerebral lobetemporal 
    Reproductivemale systemtestis   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    cell cycle     cell cycle, checkpoint, G1S
    Text placenta, lung, brain, kidney
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 40 AA F box motif
  • a F box domain
  • a CAAX motif (CVIL) (PMID;
  • twelve,leucine-rich repeats (LRR) at the C terminus
  • HOMOLOGY
    Homologene
    FAMILY
  • F box protein family
  • SCF (Skip-Cullin1-F-box protein) E3 ligase family
  • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • phosphorylation dependent ubiquination
  • substrate recognition subunit of SCF ubiquitin protein ligase complex
  • geranylgeranylated cellular protein required for hepatitis C virus RNA replication (PMID;
  • impairs cell proliferation by mediating cyclin D3 polyubiquitination and degradation
  • implicated as an indispensible regulator of mitosis that serves as a tumor suppressor (
  • role for SCF (FBXL2) in regulating the fidelity of cellular division
  • ubiquitinates and destabilizes cyclin D2 protein leading to G(0) phase arrest and apoptosis in leukemic and B-lymphoblastoid cell lines
  • is a novel and dual regulator of APP metabolism through FBXL2-dependent ubiquitination of APP
  • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • one of the four subunits of the E3 ubiquitin protein ligase complex :(SCF) with SKP1, CUL1, RBX1, F-box protein bringing ubiquitin conjugating enzymes to substrates recruited by F-box
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • various target proteins
  • uniquely recognizes a canonical calmodulin (CALM1)-binding motif within CCND3 to facilitate its polyubiquitination
  • regulates amyloid precursor protein (APP) metabolism through APP ubiquitination
  • FBXO3 potently stimulates cytokine secretion from human inflammatory cells by mediating the degradation of the TRAF inhibitory protein, FBXL2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    antiproliferative effect of FBXL2 in lymphoproliferative malignancies
    ANIMAL & CELL MODELS