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FLASH GENE
Symbol FBXL18 contributors: - updated : 07-06-2006
HGNC name F-box and leucine-rich repeat protein 18
HGNC id 21874
Location 7p22.2      Physical location : 5.515.428 - 5.553.399
Synonym symbol(s) FLJ11467, FBL18, FLJ38075
DNA
TYPE functioning gene
STRUCTURE 82.00 kb     7 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue   
Endocrinethyroid    
Reproductivemale systemprostate   
Skin/Tegumentskin    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one F box near its N terminus
  • three leucine-rich repeats
  • HOMOLOGY
    interspecies homolog to murine Fbxl18 (91.7pc)
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    basic FUNCTION may be involved in ubiquitination
    CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of SCF complex, formed by SKP1, cullin and F-box proteins
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with SKP1A and CUL1
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS