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FLASH GENE
Symbol FBXL14 contributors: SGE/npt - updated : 19-11-2019
HGNC name F-box and leucine-rich repeat protein 14
HGNC id 28624
Location 12p13.33      Physical location : 1.675.159 - 1.703.331
Synonym symbol(s) MGC40195, FBL14
DNA
TYPE functioning gene
STRUCTURE 28.17 kb     2 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 2111 - 418 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Respiratorylung    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one F-box domain
  • six leucine-rich repeats
  • HOMOLOGY
    interspecies homolog to murine Fbxl14 (99.7pc)
    homolog to rattus Fbxl14 (100.0pc)
    Homologene
    FAMILY
  • F-box protein family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • protein ubiquitin ligase
  • BTRC, FBXW7, FBXL14, FBXO45, FBXL5, FBXO11 play in controlling EMT during development and cancer progression, a process dependent on post-translational modifications that govern their interaction with target proteins
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the SCF-type 3 ubiquitin ligase complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SKIP1A and CUL1
  • interacting with the ubiquitination targets through others protein interaction domains
  • interacting with SNAU1 and promoting its ubiquitylation and proteasome degradation (Vinas-Castells 2010)
  • cell & other
    REGULATION
    Other down-regulated during hypoxia (Vinas-Castells 2010)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    decreased in tumors with a high expression of carbonic anhydrase 9 and TWIST1 (Vinas-Castells 2010)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS