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FLASH GENE

Symbol

FBP1

contributors: mct - updated : 29-11-2019

HGNC name	fructose-1,6-bisphosphatase 1
HGNC id	3606

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	FBP1D fructose-1,6-biphosphatase 1 deficiency
Location	9q22.32      Physical location : 97.365.422 - 97.402.531
Synonym name	FBPase 1
	growth-inhibiting protein 17
	D-fructose-1,6-bisphosphate 1-phosphohydrolase 1
Synonym symbol(s)	FBP
EC.number	3.1.3.11

DNA

TYPE	functioning gene
STRUCTURE	37.12 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	cytosine-phosphate-guanine/HTF
	Binding site
text structure	NFKB binding element

MAPPING

cloned

Y

linked

Y

status

confirmed

RNA

TRANSCRIPTS	type	messenger

text	two transcripts encode the same protein

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000507 7 - 1647 NP_000498 36.7 338 - 2018 30193944 NM_001127628 8 - 1546 NP_001121100 36.7 338 - 2018 30193944

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       moderately   stomach       predominantly Endocrine pancreas islet of Langerhans       Respiratory lung       highly Urinary bladder       moderately   kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Digestive acinar Endocrine islet cell (alpha,beta...)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

four binding sites for the substrate, for AMP and for divalent metal cation (zinc)

mono polymer

homomer , tetramer

HOMOLOGY

interspecies	homolog to rattus Fbp1 (85.2 pc)
	homolog to murine Fbp1 (84.9 pc)

Homologene

FAMILY

FBPase class 1 family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus

basic FUNCTION	catalyzing the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate
	important roles of FBP1 expression in lung cancer development and progression

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

carbohydrate

signaling

	gluconeogenesis
	FBP1 signaling pathway may serve an important role in normal follicle growth and hyperandrogenism&
	8209;induced abnormal development, which may be associated with abnormal glucose metabolism induced by high concentrations of testosterone

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein	FBP1 guides the cellular localization of ALDOB
	FBP1 down-regulation enhanced the activity of WNT/CTNNB1 pathway and increased the level of its downstream targets, including MYC and MMP7
	CBX3 negatively regulated FBP1 expression
	CBX3 serves as a positive regulator of aerobic glycolysis via suppressing of the FBP1 in pancreatic cancer cells
	HSF2 could regulate aerobic glycolysis by suppression of FBP1 to support uncontrolled proliferation of hepatocellular carcinoma cells
	TRIM47 promoted the aerobic glycolysis of pancreatic cancer cells, which was largely dependent on the direct binding to and ubiquitination of FBP1

cell & other

REGULATION

inhibited by

AMP

Other	allosteric enzyme
	allosteric inhibitor

ASSOCIATED DISORDERS

corresponding disease(s)

FBP1D

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   may repress tumor growth, migration and glycolysis via targeting HIF1A in basal-like breast carcinoma tumoral     --over   is a critical modulator in breast cancer progression by altering glucose metabolism and the activity of WNT/CTNNB1 pathway

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	potential use of the methylation status detected in FBP1 promoter region as a novel predictor for prognosis and therapeutic target for NSCLC (Non-Small Cell Lung Cancer) patients
Therapy target
	System Type Disorder Pubmed cancer brain glioma/neuroblstoma FBP1 is a potential therapeutic target regulating glioblastoma (GBM) metabolism following radiotherapy cancer endocrine pancreas disrupting the CBX3-FBP1 signaling axis would be effective to treat pancreatic cancer and prevent aerobic glycolysis

ANIMAL & CELL MODELS